The federal Project Grant award R01DK138677, totaling $689,050, was granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to define the roles of the Gli1 periportal mesenchyme and the epithelial Ihh in regulating epithelial-periportal mesenchymal crosstalk during intrahepatic bile duct (IHBD) development. This research seeks to improve the understanding of epithelial-mesenchymal interactions, which could enable the development of targeted therapies to augment IHBD architecture and bile duct formation in diseases associated with IHBD paucity. The award includes a $235,493 sub-grant to Cincinnati Children's Hospital Medical Center, which will be responsible for conducting experiments, providing reagents, and analyzing results related to the proposed studies involving mice.
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