Project Grant K01DA062777
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $671,732.00 to The Washington University to conduct research on the mechanisms underlying fentanyl-induced cardiorespiratory depression. The project aims to evaluate peripherally-acting mu opioid receptor antagonists as a potential treatment strategy to reverse opioid-induced respiratory depression without precipitating withdrawal or aversion, which is a...
- This federal Project Grant award for $340,000 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to better understand the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal-induced negative affect behaviors. The research aims to determine whether a newly identified midbrain glutamatergic input to the LC contributes to the negative affective behaviors associated with opioid withdrawal....
- This Project Grant award in the amount of $428,432 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The objective of this project is to advance the basic understanding of the mechanism of action and structure-activity relationship of the highly potent synthetic opioid derivatives known as "nitazenes" in comparison to fentanyl. The project will leverage state-of-the-art simulations, machine learning, and experimental...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $139,927 to the University of Washington to study the impact of chronic, voluntary fentanyl intake on gene expression and neural activity patterns in the brain. The key objectives are to: 1) Conduct single-cell RNA sequencing analysis of the nucleus accumbens to assess changes in gene expression following chronic fentanyl self-administration and...
- This Project Grant from the National Institutes of Health National Institute on Drug Abuse, under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $640,000 to Olfa Thera, Inc. to develop new therapeutics targeting the OLFR78/OR51E2 receptor pathway in the carotid body. The goal is to identify OLFR78/OR51E2 agonists that can strongly stimulate carotid body activity and ventilation to reverse opioid-induced respiratory depression, without the side effects of existing...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to Dr. Nicholas Burgraff to conduct research aimed at understanding the neurophysiological mechanisms by which opioids disrupt respiratory function and lead to airway constriction. The research seeks to identify new therapeutic approaches to mitigate the life-threatening respiratory complications of opioid overdose. The award will...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a wireless bioelectronic system for high-performance fentanyl monitoring in the brains of freely moving small animal models. The $358,371 award, effective from October 1, 2025 to September 30, 2028, will support three key objectives: Isolating, characterizing, and engineering aptamers (targeting molecules) for the primary opioid fentanyl associated with opioid use...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $193,250 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Trustees of Tufts College, doing business as Tufts University School of Medicine in Boston, Massachusetts. The grant, awarded on September 15, 2025, aims to determine whether fentanyl overdose induces an anhedonic phenotype, which in turn increases the risk of relapse in individuals with opioid use...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), part of the U.S. Department of Health and Human Services, is funded through the Drug Use and Addiction Research Programs (CFDA 93.279). The $454,251 award will support the development of a new approach for long-term monitoring of opioid-induced changes in neural population activity and opioid receptor gene expression in mice exposed to fentanyl. Specifically, the project aims to create "erasable"...
- This Project Grant award of $587,188.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a multi-omics research study on the impact of fentanyl use on cells susceptible to HIV infection. The research aims to evaluate the effects of fentanyl on the single-cell transcriptome and microRNA profiles in various peripheral blood mononuclear cell types, including CD4+ and CD8+ T lymphocytes, monocytes, B lymphocytes, dendritic...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $495,950 to The Washington University in Missouri to investigate the mechanisms involving mu opioid receptor (MOR) signaling within the nucleus of the solitary tract (NTS) that contribute to fentanyl-induced cardiorespiratory depression. The 3-year project, commencing on Sept 1, 2025, aims to employ various techniques such as chemogenetics, optogenetics, and fiber photometry to evaluate presynaptic and postsynaptic mechanisms of fentanyl-MOR signaling in the NTS, as well as examine how vagal afferent fibers mediate the activity of catecholaminergic and GABAergic NTS neurons and how fentanyl impacts this vagal signaling. The goal is to enhance understanding of opioid-induced respiratory depression, a critical challenge due to the rapid onset of effects from synthetic opioids like fentanyl.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $496.0k | 8/19/25 |