This $166,037 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to determine the impact of CDK4/6 inhibition on the progression of intraductal papillary mucinous neoplasms (IPMN), a precursor to pancreatic cancer. The research will be conducted by the University of California, San Diego, leveraging genetically modified mouse models and patient-derived xenograft models to analyze tumor progression, survival, and the tumor microenvironment following CDK4/6 inhibition. The goal is to provide translational data to support future clinical trials for this targeted intervention strategy against IPMN, which can lead to the lethal pancreatic ductal adenocarcinoma. The award period runs from April 1, 2025 to March 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $166.0k | 3/21/25 |