This Project Grant award, with a total funding amount of $130,302.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award, with an effective date of July 15, 2025 and an ultimate completion date of March 31, 2030, supports research at New York University (NYU) to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons and its consequences for Alzheimer's disease progression. The research aims to elucidate the interplay between tau pathology and cholinergic dysfunction, leveraging human induced pluripotent stem cell models and a novel mouse model with restricted tau expression in basal forebrain cholinergic neurons. The findings are expected to provide insights into tau pathogenesis in cholinergic dysfunction and degeneration, and inform potential therapeutics to improve the resilience of these neurons in treating Alzheimer's disease and related tauopathies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $130.3k | 7/8/25 |