Project Grant K01AA033159
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $149,190 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to explore the role of medial prefrontal cortex corticotropin-releasing factor circuitry in stress-enhanced alcohol consumption. The research examines how chronic alcohol exposure and chronic stress alter corticotropin-releasing factor (CRF) and CRF receptor 1 (CRFR1) neurons in the prelimbic cortex, a key brain...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $154,300 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate neuroplasticity as a mechanistic link between adverse life experiences and adolescent alcohol use. The project leverages the Adolescent Brain Cognitive Development Study through three specific research aims. Aim 1 examines whether adverse experiences during adolescence alter neuroplasticity in...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $628,080 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. This Project Grant (R01AA032487) funds a five-year investigation into whether a hyperactive nociceptin opioid peptide receptor (NOP) system drives relapse in heavy drinking alcohol use disorder (AUD) subjects, using positron emission tomography imaging with [11C]NOP-1A radiotracer and hydrocortisone challenge protocols. Prior...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of North Carolina at Chapel Hill $444,576 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to evaluate GLP-1 receptor agonists on alcohol-related behaviors. The recipient will conduct a preclinical screening pipeline assessing how GLP-1 receptor agonist compounds—including semaglutide, tirzepatide, and retatrutide—affect alcohol subjective and interoceptive effects and alcohol reinforcement in the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Brown University $1,429,670 on September 18, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a 12-week, double-blind, randomized controlled trial testing probenecid as a treatment for alcohol use disorder. The study enrolls 120 individuals with alcohol use disorder and compares probenecid (2 grams daily) to placebo across three primary aims: reducing acute alcohol craving in an alcohol cue reactivity procedure,...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical College of Wisconsin, Inc., $248,959 on September 12, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year longitudinal study examining reciprocal associations between brain function and alcohol use trajectories in adolescents and young adults. The recipient will assess prospective long-term associations between reward processing, cognitive control, and alcohol use patterns using two large...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $752,580 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year experimental medicine trial examining semaglutide dose effects on metabolic dysfunction, stress hormones, craving, and alcohol use outcomes in individuals with comorbid alcohol use disorder and obesity. The trial compares semaglutide at 1 milligram and 2 milligram doses against placebo over a 20-week treatment period and...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $211,659 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to support a K23 Mentored Patient-Oriented Research Career Development Award funding Dr. Margaret Baer's research program. Dr. Baer will develop a novel single-session intervention for alcohol craving and suicide ideation, then conduct a micro-randomized clinical trial to generate preliminary evidence on the most...
The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $195,912 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate oleoylethanolamide (OEA) as a therapeutic intervention for alcohol use disorder in young adults. The recipient will conduct a randomized, double-blind, placebo-controlled clinical trial evaluating six weeks of OEA supplementation at 125 milligrams per day in 42 young adults ages 18 to 25 with alcohol use disorder. The study measures peripheral inflammation markers (IL-6, TNF-α, IL-1β, LPS), oral microbiome composition, neurocognitive function related to reward and impulsivity, and alcohol use outcomes via self-report and biomarkers. The research targets multiple biological systems simultaneously—neural, immune, and microbial networks—to identify objective indicators of treatment response and generate translatable insights into the mechanisms underlying alcohol use disorder during a period of peak prevalence and ongoing neurodevelopment. The project runs through July 31, 2031, with place of performance in Charleston, South Carolina. This is a K01 career-development grant award, a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $195.9k | 7/24/26 |