Project Grant R01AA031963
- This federal Project Grant award of $2,150,570 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Brown University. The funding supports research to investigate the circuit and molecular mechanisms through which alcohol influences natural reward systems in the brain. Specifically, the project aims to use the reduced numerical complexity of the Drosophila (fruit fly) reward/dopaminergic system as a model to study...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $197,302 to Brown University to develop a virtual reality-based intervention to help adults with alcohol use disorder learn and practice coping skills in realistic high-risk situations. The goal is to improve the efficacy of treatment for alcohol use disorders, which affect over 100 million people worldwide and are a leading cause of...
- This Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), which falls under the federal Alcohol Research Programs (CFDA 93.273). The $692,723 award will support a double-blind, placebo-controlled clinical trial to test whether the drug suvorexant can be used as a novel therapeutic for alcohol use disorder (AUD) and stress-related drinking. The 5-year project, running from September 2025 through August 2030, will be conducted by researchers at The...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $498,002 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Illinois to conduct a study aimed at increasing alcohol abstinence in young adults with alcohol use disorder (AUD). The overall goals of this 3-year project are to: (1) test the efficacy of combining contingency management (CM) with problem-solving therapy (CM-PST) versus CM alone in a 2-arm pilot randomized controlled trial, and...
- This $856,625 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports an exploratory randomized controlled trial (RCT) of the effects of oral semaglutide on alcohol craving and consumption. The University of Colorado-Denver, as the prime awardee, will conduct this 2-year study to assess the safety, tolerability, and efficacy of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, compared to placebo...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $901,666 Project Grant to Research Triangle Institute (RTI International) to develop small molecule modulators of the RXFP3 receptor as potential therapeutic agents for alcohol use disorder (AUD). The project aims to further optimize and evaluate the effectiveness of the RXFP3 negative allosteric modulators (NAMs) RLX-33 and RLX-79 in animal models of alcohol...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $431,918 in funding to Bryant University for a research project focused on understanding the neural circuitry mechanisms underlying maladaptive reward memories related to alcohol addiction. The research aims to use the genetic tractability of the Drosophila melanogaster model organism to investigate how alcohol disrupts memory circuit activity and drives...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $733,137 to Brown University to conduct a 12-week, double-blind, randomized controlled trial investigating the effects of the drug probenecid on alcohol craving and consumption in 120 individuals with alcohol use disorder. The goal is to replicate and expand upon the team's prior preclinical and human laboratory findings demonstrating probenecid's potential to reduce acute alcohol craving and consumption. The study includes three specific aims: 1) to evaluate the impact of probenecid on acute alcohol craving in an alcohol cue reactivity procedure, 2) to assess probenecid's effects on alcohol craving over the 12-week trial, and 3) to examine probenecid's influence on overall alcohol consumption during the trial. An exploratory aim will also investigate probenecid's impact on pro- and anti-inflammatory markers. This award began on September 18, 2025 and is expected to be completed by August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $733.1k | 9/18/25 |