Project Grant HT9425261E076
- Federal Project Grant Award Summary The Defense Health Agency (DHA) awarded Duke University $696,154 under the Military Medical Research and Development program (CFDA 12.420) to investigate off-target effects of breast cancer adjuvant radiation therapy on thymus function in young women. The three-year project, initiated September 1, 2026 and concluding August 31, 2029, will be conducted at Duke University's Durham, North Carolina facility. The research addresses a critical gap in understanding...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $845,250 by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) beginning July 1, 2025, through June 30, 2028. The project focuses on engineering T-cell receptor (TCR)-modified T cells designed to target human endogenous retroviruses for non-small cell lung cancer immunotherapy. This research initiative represents an advanced biomedical research...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $700,032 Project Grant award from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective August 1, 2025, through July 31, 2029. The award supports research titled "Imaging Strategies and Biomarkers for Detecting the Metabolic Interplay of Glutamine and Aspartate in RCC" (Renal Cell Carcinoma), with work performed at Duke's Durham,...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $1.54M project grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) effective September 1, 2025, through August 31, 2028. The award funds research activities focused on assessing prognoses and validating surrogate endpoints for clinical outcomes in metastatic hormone-sensitive prostate cancer. This research initiative aligns with the Defense...
- Federal Project Grant Award Summary Award: The Defense Health Agency (DHA), through its Military Medical Research and Development program (CFDA 12.420), awarded Duke University's Office of Research Administration a Project Grant of $564,705 on September 15, 2025, for research extending through September 14, 2028. The award supports the identification of oncofusion-interacting proteins as essential drug targets for common and rare oncofusions in rhabdomyosarcoma. This research initiative aligns...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $489,987 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective September 1, 2026 through August 31, 2029. The award funds research investigating metastasis-initiating cells and lung repair mechanisms as drivers of metastasis in undifferentiated pleomorphic sarcoma (UPS), with the aim of developing biologic and...
- This federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $724,500.00 to Duke University to conduct research aimed at "TARGETING DORMANCY-ASSOCIATED IMMUNE TOLERANCE TO ELIMINATE RESIDUAL BREAST CANCER." The award period runs from March 1, 2025 to February 29, 2028. As a leading private research institution, Duke University's Office of Research Administration will leverage its multidisciplinary...
- Federal Grant Award Summary The Defense Health Agency (DHA) awarded a $750,000 Project Grant to the University of California Irvine on May 1, 2026, under the Military Medical Research and Development program (CFDA 12.420) for the project "A Novel Strategy to Improve the Effectiveness of Radiation Therapy in Breast Cancer." The three-year award period runs through April 30, 2029, and supports investigator-initiated biomedical research addressing medical challenges relevant to Service...
- This Defense Health Agency Project Grant award of $1,204,899 to Duke University, with a period of performance from January 1, 2024 to December 31, 2027, supports targeted vaccination research to treat and prevent endocrine-resistant ER+ breast cancer. The project aims to develop new treatments by targeting common resistance genes and neoepitope mutations. This grant is funded through the Department of Defense's Military Medical Research and Development program (CFDA 12.420), which supports...
- Duke University was awarded a $931,969 project grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant will fund research from July 1, 2023 to June 30, 2026 to develop epigenetic signatures to predict pathological nodal stage for de-escalation of axillary surgery in patients with clinically node-positive breast cancer. The research aims to transform patient care by investigating medical solutions that could help reduce the need...
Duke University's Office of Research Administration received a $553,848 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), effective September 1, 2026 through August 31, 2029. The project, titled "Off-Target Effects of Breast Cancer Adjuvant Radiation Therapy on Thymus Function in Young Women," will investigate the unintended immunological consequences of radiation therapy in female breast cancer patients. The research addresses a critical gap in understanding how standard cancer treatment protocols affect thymic function and immune system development in younger female populations, supporting the Defense Health Agency's mission to advance medical solutions for Service Members' health. The three-year investigation will be conducted at Duke University's Durham, North Carolina campus and will leverage the institution's established research infrastructure and expertise in oncology and biomedical research. This award represents one of the Military Medical Research and Development program's Project Grants, which constitute 88 percent of the program's portfolio and typically support investigator-initiated research addressing medical conditions affecting the military population. The research outcomes are expected to inform clinical practice and improve long-term health outcomes for female Service Members and beneficiaries receiving breast cancer adjuvant radiation therapy.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $553.8k | 6/16/26 |