Project Grant HT94252510120

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $206,198 to New York Medical College to investigate the role of DNA polymerase delta 4 (POLD4) in lung carcinogenesis induced by genotoxic carcinogens. The project aims to characterize the effects of lung carcinogens, including hexavalent chromium, benzo(a)pyrene, and nicotine-derived nitrosamine ketone, on the degradation of the...

This $548,707 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to examine the effects of hexavalent chromium (Cr(VI)) exposure on skeletal muscle development and regeneration. The research will be conducted by the New York University School of Medicine over a one-year period from September 2024 to August 2025. The key objectives are to: 1) assess the impact of acute or chronic Cr(VI) exposure on...

This $1,138,458 Project Grant award, provided by the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program, supports research by the University of Chicago to study the role of fungi (mycobiomes) in lung cancer development and progression. The project aims to: 1) establish the carcinogenic effects of specific fungal species like Aspergillus fumigatus and Alternaria on lung cancer, 2) understand the mechanisms of fungal-induced DNA mutations and oxidative damage, and 3)...

The National Cancer Institute (NCI) awarded a $392,040 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to Weill Medical College of Cornell University. The grant will fund a 5-year research project to study the role of propionate metabolism in non-small cell lung cancer (NSCLC). The research aims to: Elucidate the mechanism by which methylmalonic acid (MMA), a byproduct of propionate metabolism, signals in NSCLC cells. Investigate the effects of MMAB gene knockdown, a key...

The federal Project Grant award K23ES035447 was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program. The $241,811 award supports research to investigate the relationship between air pollution exposure, social vulnerability, and the development of progressive pulmonary fibrosis (PPF) in patients with interstitial lung disease (ILD). The principal investigator, Dr. MacMurdo, aims to leverage a unique patient cohort to:...

This Project Grant award of $527,300.00 from the National Institute of Environmental Health Sciences (NIEHS) supports research conducted by the Regents of the University of Michigan to investigate the mechanisms driving lung fibrosis in response to silica and asbestos inhalation. The research aims to understand why transitional alveolar epithelial cells lose the ability to differentiate into normal alveolar cells in silicosis and asbestosis, leading to persistent fibrosis. The study will...

This $186,075 Project Grant was awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The grant will support research to investigate the role of the ACOD1-itaconate immunometabolic pathway in regulating lung monocyte/macrophage inflammatory processes in response to environmental exposures that can cause lung disease. Specifically, the research aims to 1) determine the functional effects of the...

This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to target the SWI/SNF chromatin remodeling complex subunit SMARCA2 as a therapeutic approach for non-small cell lung cancers with SMARCA4 deficiencies. The $557,418 grant will fund a 5-year project at The Trustees of Columbia University in the City of New York to: 1) assess the effects of SMARCA2 degradation on SMARCA4-deficient lung cancer progression using genetically...

This Project Grant award, funded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate the role of proteolytic extracellular vesicles (EVs) in mediating chronic lung injury following exposure to halogen gases such as chlorine (Cl2) or bromine (Br2). The key objectives are to: 1) Determine the role of neutrophil-derived EVs in driving chronic lung injury after halogen gas exposure, and 2) Assess the...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $153,130 to the University of California, San Diego to study the role of a novel population of fibroblasts in the progression of pulmonary fibrosis. The principal investigator, Dr. Xu, will use cutting-edge technologies to determine the cellular origins, molecular drivers, and functional roles of these subpleural fibroblasts in...