This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to decipher the role of mycobiomes (fungal microbiomes) in lung carcinogenesis. The $1,138,458 award, granted on December 1, 2024, supports a research project led by the University of Chicago that utilizes an innovative 3D-organotypic lung model derived from human pluripotent stem cells. The research focuses on three key objectives: 1) Establishing the carcinogenic effect of fungi, particularly Aspergillus fumigatus, on lung cancer; 2) Understanding the mechanisms of fungal mutagenesis, including direct and indirect pathways involving mycotoxins and reactive oxygen species; and 3) Determining the impact of fungus-induced remodeling of host immunity on lung cancer. The project is expected to run through November 30, 2029 and could lead to the development of new diagnostic, preventive, and therapeutic strategies for cancer influenced by mycobiomes.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 2/12/25 | ||
| Not listed | $569.2k | 11/29/24 | ||
| Not listed | $569.2k | 11/29/24 |