Project Grant HT94252311037

This $2.11 million project grant from the National Science Foundation's Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), will fund research at Emory University and the University of Tennessee from March 2023 through February 2027 to rationally design long noncoding RNAs (lncRNAs) for epigenetic signal amplification. The researchers will define the minimal features required for large-scale silencing mediated by lncRNAs, building on the...

The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $2,129,028 Project Grant to New York University (NYU) under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural dynamics and function of long non-coding RNAs (lncRNAs). The research project aims to establish NYU as a world-leading expert in connecting lncRNA structural dynamics to their biological functions. The research team, which includes high school, undergraduate,...

This three-year $872,936 project grant from the National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, will fund research into the regulation of the microglial neuroimmune response by long non-coding RNAs. The grantee, Creighton University, will investigate how specific long intergenic non-coding RNAs (lincRNAs) mediate a proinflammatory state in microglia and determine if differential lincRNA expression underlies viral-induced mouse models of...

This Project Grant award of $104,952 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research into RNA decay mechanisms that regulate Long Interspersed Element-1 (LINE-1 or L1) retrotransposons in B cells. The goal is to investigate how the RNA exosome, an 11-subunit RNA processing and degradation complex, targets and degrades L1 RNA to maintain B cell genome integrity. The 2.5-year...

This $495,000 National Science Foundation project grant supports collaborative research at the University of Colorado Denver to explore the potential role of non-coding RNAs in encoding molecular memory. Funded under the Biological Sciences program (CFDA 47.074), the three-year award beginning May 1, 2023 will examine whether a simple form of memory known as behavioral sensitization can be stored by non-coding RNA. The principal investigators hypothesize that expression or post-transcriptional...

This federal Project Grant award of $714,110.00 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) will support research by New York University School of Medicine to translate insights in follicular lymphoma for improved diagnosis and classification. The research aims to identify reliable predictive biomarkers to guide frontline risk stratification and treatment for high-risk follicular lymphoma patients, who face a poor prognosis due to early disease...

This Project Grant award for $468,139, provided by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research at Tulane University to investigate the role of the long non-coding RNA CRNDE in suppressing the immune response to hepatocellular carcinoma. The project aims to elucidate the molecular mechanisms by which CRNDE inhibits tumor-infiltrating lymphocytes, and to evaluate the in vivo anti-cancer efficacy of CRNDE inhibition in mouse models. The...

The Regents of the University of Michigan received a $381,853 project grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to investigate the nuclear entry mechanisms of two DNA viruses - the oncogenic Merkel cell polyomavirus (MCPyV) and the oncolytic LuIII parvovirus. Over a 5-year period ending June 2030, the research will use molecular biology, biochemistry, and microscopy techniques to determine how these viruses...

This $1,555,035 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will fund research into the discovery of novel functional RNA classes through computational integration of massively-parallel RBP binding and structure data. The award was made under the Biological Sciences federal grant program (CFDA 47.074) to support basic biological research strengthening the nation's scientific enterprise. The California Institute of Technology will use the...

This National Science Foundation Project Grant of $708,083 will fund research into circular RNAs as a primate-specific mechanism for proteome diversity from August 15, 2022 to July 31, 2025. Under the Biological Sciences program (CFDA 47.074), the University of Kentucky Research Foundation will investigate the molecular mechanisms by which circular RNAs are translated after adenosine-to-inosine editing. Researchers will characterize factors influencing circular versus linear RNA splicing and...