Project Grant 2221921
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The University of Kentucky Research Foundation a $595,769 Project Grant effective September 15, 2025, through August 31, 2030, under the Aging Research program (CFDA 93.866). This award supports scientific research investigating the role of RNA modifications in the translation of circular ribonucleic acids (circRNAs) and their pathophysiological consequences in Alzheimer's disease. The research will examine how...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
- This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
- The National Science Foundation awarded $665,786 under the Biological Sciences federal grant program (CFDA 47.074) to the University of North Carolina at Chapel Hill from March 2023 through February 2027. The project aims to advance understanding of long noncoding RNAs (lncRNAs) and their potential for epigenetic regulation through rational design and engineering of synthetic lncRNAs. Researchers will define the minimal features required for large-scale silencing mediated by lncRNAs, building...
- This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
- This National Science Foundation (NSF) Biological Sciences program grant to Yale University, totaling $940,000 over 3 years beginning March 1, 2024, aims to systematically identify features of human and viral messenger RNAs (mRNAs) that regulate protein production. The project will employ a massively parallel reporter assay to quantify the impact of RNA modifications, structured RNA elements, and cell-specific factors on mRNA translation. Insights gained will provide a comprehensive...
- This $469,407 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will fund research to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The awardee, Georgia Tech Research Corporation, will conduct this research from March 2023 through February 2028. Specifically, the organization will...
This National Science Foundation Project Grant of $708,083 will fund research into circular RNAs as a primate-specific mechanism for proteome diversity from August 15, 2022 to July 31, 2025. Under the Biological Sciences program (CFDA 47.074), the University of Kentucky Research Foundation will investigate the molecular mechanisms by which circular RNAs are translated after adenosine-to-inosine editing. Researchers will characterize factors influencing circular versus linear RNA splicing and associated proteins. They will also test selected circular RNA functionality in biochemical and cell-based assays. Additionally, the University of Kentucky will partner with researchers in Israel to organize annual RNA summer schools featuring theoretical lectures and practical courses. Lectures will be recorded, subtitled in multiple languages, and published online and in an accompanying textbook to train the next generation of RNA biologists.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $708.1k | 8/15/22 |