Project Grant F32CA132308

This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) provides $411,400 to Northwestern University to develop and characterize a cell culture model of Kaposi's sarcoma (KS). The primary objective is to identify KSHV-induced cellular genes that promote the loss of contact inhibition of proliferation (CIP) in KSHV-infected lymphatic endothelial cells (KLECs), which are believed to be the cell of origin for KS tumors. The...

The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $430,285 Project Grant to Towson University to investigate RTA-induced ubiquitination in Kaposi's Sarcoma Herpesvirus (KSHV) for the period of February 1, 2025 to January 31, 2028. The project aims to identify cellular targets for intervention by studying novel virus-host interactions involving the cellular ubiquitin-proteasome...

This Project Grant award of $892,050.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Missouri at Kansas City (UMKC) to investigate how plant viruses modulate host chromatin dynamics and gene expression. The key objectives are to: Determine how the PEMV2 virus P26 protein induces chromatin compaction and alters host gene expression, potentially repressing...

Federal Cooperative Agreement Award Summary The National Cancer Institute (NCI) awarded a $4.86 million Cooperative Agreement to the University of California, Los Angeles (UCLA) under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, to develop a strategically engineered multi-antigen Kaposi Sarcoma-Associated Herpesvirus (KSHV/Human Herpesvirus-8) vaccine through August 31, 2029. The project addresses a significant global health challenge, as KSHV infection accounts for...

This three-year Project Grant award of $445,500 from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports fundamental research conducted by the Board of Trustees of Southern Illinois University to elucidate the regulatory mechanisms controlling SGF73/ATAXIN-7, a key component of the SAGA (SPT-ADA-GCN5-ACETYLTRANSFERASE) transcriptional co-activator complex. The research aims to identify and characterize the ubiquitin-proteasome system (UPS) regulation of...

Federal Cooperative Agreement Summary The National Cancer Institute awarded Fred Hutchinson Cancer Center a $4.23 million Cooperative Agreement on September 19, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct comprehensive characterization of the T-cell response to Kaposi Sarcoma Herpesvirus (KSHV). The project, extending through August 31, 2029, focuses on identifying and understanding KSHV-specific T-cell responses in individuals with and without HIV infection,...

Federal Project Grant Award Summary Emory University was awarded $234,156 on February 28, 2026, through the National Institute of Allergy and Infectious Diseases (NIAID) Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on capsid assembly mechanisms of Kaposi Sarcoma Associated Herpesvirus (KSHV). The research project, scheduled for completion by October 31, 2028, will deliver scientific knowledge and methodological advances regarding herpesvirus capsid...

This $536,943.46 Project Grant from the National Institutes of Health National Institute of Allergy and Infectious Diseases funds research at The Scripps Research Institute-Florida on identifying host factors that regulate HIV latency and reactivation. The grant supports three aims over a six-month period: defining the roles of proteins P32, FUBP3, and PHB2 in HIV transcription and chromatin structure; investigating protein complexes associated with P32, FUBP3, and PHB2 and their interaction...

The National Institutes of Health National Institute of Allergy and Infectious Diseases awarded $852,121.24 to The Scripps Research Institute-Florida under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of July 22, 2021 through October 31, 2021. The project aims to identify host factors that regulate HIV latency and reactivation in order to develop strategies for durable HIV silencing. The grantee will define the roles of three identified host factors, P32,...

Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded the University of Arkansas for Medical Sciences $583,289 under the Oral Diseases and Disorders Research program (CFDA 93.121) for a Project Grant focused on epigenetic regulation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) latency. The award, effective July 1, 2025, through March 31, 2030, supports research investigating how KSHV maintains viral dormancy and escapes immune surveillance in...