Project Grant R15CA290595
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- The federal Project Grant award of $160,330 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) is supporting research by the University of Illinois to investigate the biochemical determinants of genome instability induced by eukaryotic topoisomerase II. The project aims to determine how the biochemical properties of topoisomerases, along with factors like chromatin structure and DNA repair pathways, influence genome instability. This research builds on the...
- This federal Project Grant award of $156,980 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Mechanisms of SAGA Regulation by Histone Crosstalk". The project aims to study the acetylation activity of the SAGA transcriptional co-activator complex on mono- and di-nucleosomes with biologically relevant post-translational modifications. This research will...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) totaling $138,489 will support research to develop a "Methyl Arginine Targeting Chimera for the Lysosomal Degradation of Intracellular Proteins". The project aims to characterize a novel approach to targeted protein degradation that utilizes lysosomal pathways, rather than the traditional proteasomal system, to eliminate disease-causing proteins. This innovative research has the...
- The National Cancer Institute (NCI) awarded a $768,437 project grant under the Cancer Treatment Research program (CFDA 93.395) to the Sanford Burnham Prebys Medical Discovery Institute (SBP) to implement high-throughput screening assays to identify chemical compounds that inhibit the chromatin reader protein SGF29. This target is of interest as it has been identified as a regulator of oncogenic transcription factors aberrantly activated in acute myeloid leukemia (AML), a disease with poor...
- This federal Project Grant award, valued at $849,371.00, was issued on August 2, 2024 by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The grant supports research aimed at "Hijacking Post-Translational Arginylation for Targeted Protein Degradation" at the Washington University in St. Louis. The key research activities include: Applying computational techniques to identify potential ATE1 binder hits for targeted protein degradation....
- This Project Grant award of $449,726.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Illinois aims to develop innovative tools for rapidly mapping dynamic changes in protein interactions within living cells. The goal is to enable the facile analysis of protein interaction changes occurring within one minute or less, which will significantly improve the sensitivity and temporal resolution of existing approaches. The project will explore three...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- This $467,599 project grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a 5-year research program at Syracuse University to study the architecture and function of ubiquitin-containing biomolecular condensates involved in protein quality control pathways. The research aims to achieve a mechanistic understanding of how ubiquitin-binding shuttle proteins regulate the assembly, disassembly,...
- This federal Project Grant award of $194,914 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the role of trans-acting factors and cis-element sequences in activating oncogenes in rearranged human genomes. The awardee, the University of Texas Health Science Center at Houston, will employ CRISPR/Cas9 genome engineering to introduce chromosomal translocations near oncogenes and model their expression using single-cell multi-omic...
This federal Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting research to decipher the regulation of the protein SGF73/ATAXIN-7, a key component of the SAGA transcriptional co-activator complex. The $445,500 award to the Board of Trustees of Southern Illinois University will fund experiments to identify the E3 ubiquitin ligase responsible for SGF73 ubiquitylation and proteasomal degradation, determine the ubiquitylation site on SGF73, and establish the physiological relevance of SGF73 regulation by the ubiquitin-proteasome system on SAGA's integrity and gene expression functions. This research aims to advance understanding of the fundamental biological mechanisms controlling gene expression, with potential implications for cancer, eye, and neurological disorders where SGF73 dysregulation has been observed.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.5k | 8/8/25 |