This Federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $497,083.00 to support research on the mechanisms of fetal skin regeneration. The grant aims to elucidate the genetic and molecular basis of scarless, multi-lineage regeneration in fetal skin after injury, in contrast to the fibrotic healing observed in postnatal skin. The research team at Harvard University will leverage novel in vivo techniques, including single-cell multi-omic analysis, to develop comprehensive cellular and molecular atlases of fetal versus postnatal wound healing processes. The overarching goal is to identify key factors that inhibit or promote regenerative healing, which could inform the development of new therapeutic strategies to enhance regeneration for challenging skin injuries and chronic wounds.
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