Project Grant 2421118
Award Date
10/1/24
Completion Date
9/30/28
Dollars Obligated
$225K
Federal Agency
Division of Integrative Organismal Systems
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92697, USA
Similar Awards
This Project Grant award of $251,118.00 from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports a collaborative research project to investigate the shared genetic and cellular mechanisms underlying limb and fin regeneration in vertebrates. The key objectives of the research are to: 1) test whether rapid activation of the mTOR signaling pathway is a conserved feature of limb and fin regeneration, 2) use transcriptomic and epigenetic profiling to...
This $1,174,440.00 federal Project Grant award, funded by the National Science Foundation (NSF) Division of Integrative Organismal Systems (CFDA 47.074 Biological Sciences), supports collaborative research to identify the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research team at Louisiana State University, the prime awardee, is using a comparative approach across three animal models - salamanders, lungfish, and Polypterus - to uncover the core...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to advance understanding of the molecular mechanisms driving limb regeneration in the Mexican axolotl salamander. The $390,101 award to Wake Forest University will develop and validate new viral gene delivery tools in the axolotl limb to enable gain-of-function and...
This federal Project Grant award for $169,000.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a single-cell reference atlas of axolotl embryogenesis. The overarching goal is to elucidate the fundamental biological processes required for limb regeneration, with the aim of informing future regenerative medicine strategies for human limb injuries...
This federal Project Grant award of $116,354, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research to develop a mathematical theory for the biological concept of modularity. The research aims to define modular structures in biological systems, such as gene regulatory networks underlying salamander limb regeneration and hormone regulation in plants, in a...
The National Science Foundation awarded a $315,757 Project Grant to Simmons University under the Biological Sciences program (CFDA 47.074) for the period of April 1, 2021 through March 31, 2024. The grant aims to advance understanding of the developmental genetics underlying limb initiation in amphibians. Specifically, the university will conduct research to determine the cellular origins and molecular mechanisms that drive limb formation in metamorphosing frogs. Researchers will use...
This $210,720 federal project grant was awarded by the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The project aims to define modular structures in biological systems in a mathematically rigorous way, and determine how modularity can be advantageous to organisms and advance the understanding of molecular systems. The research will study the modularity of gene regulatory networks underlying...
The National Institute of General Medical Sciences (NIGMS) awarded a $242,964 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Oregon. The award will support 2 years of fellowship training and research to understand the mechanisms of cell state transitions underlying organ size control during zebrafish fin regeneration. The research will leverage computational and quantitative imaging approaches to identify fibroblast-lineage cell...
This $536,617 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the mechanisms of neural regeneration in model organisms. The primary awardee, Oregon Health & Science University, will conduct experiments using planarians and zebrafish to investigate how adult neural stem cells can regenerate neural tissue and restore...
This Project Grant award, funded by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), supports research on how the hormone aldosterone regulates amphibian metamorphosis from aquatic to terrestrial forms. The $629,995 award to the University of Cincinnati, with a performance period from September 2024 to August 2027, aims to reveal aldosterone's precise role in frog development by measuring corticosteroid levels, comparing wild-type and mutant tadpoles,...