Project Grant R01AI187276
- This Project Grant award, valued at $160,040.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research conducted by the University of California, San Francisco (UCSF) to investigate how the bacterial pathogen Pseudomonas aeruginosa senses and responds to mechanical deformation of its cell envelope when contacting surfaces. The research aims to further...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This $430,375.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel inter-membrane lipid signaling mechanism in Gram-negative bacteria like E. coli and Pseudomonas aeruginosa. The research aims to elucidate how these bacteria can sense and respond to deficiencies in their outer membrane lipopolysaccharide (LPS) content, a critical component for...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $105,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Dartmouth College to study the dual function of the T6SS immunity protein TSIT in regulating Pseudomonas aeruginosa biofilm growth. The research aims to test the hypothesis that TSIT acts as a transcription factor, in addition to its role as a T6SS immunity protein, to regulate biofilm formation - a key...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the molecular determinants and functions of bacterial polysaccharide cellular localization, with a focus on the Pseudomonas aeruginosa biofilm exopolysaccharides PSL and PEL. The $783,557 award to the University of Washington aims to examine modifications to these exopolysaccharides, explore how the SIA system controls their...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,915 Project Grant to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The grant, awarded under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research to understand how polyphosphate, a polymer produced by bacteria in response to stress, interacts with the...
- This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to exploit bacteriophages (viruses that infect bacteria) to discover novel anti-biofilm agents. The goal is to improve phage therapy and identify proteins that could be developed as stand-alone therapeutics to treat biofilm-associated infections, which are a particular concern for the opportunistic pathogen Pseudomonas aeruginosa....
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate the role of a Pseudomonas bacteriophage (PF phage) in promoting chronic biofilm lung infections in individuals with cystic fibrosis. The $192,672 award, effective from September 1, 2025 to August 31, 2030, will support research at Stanford University to study how the PF phage mediates...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $569,210 to the University of Colorado Boulder to conduct research on the "Mechanisms of Lipid A Modification Impacting Antimicrobial Resistance". The key focus is on understanding how certain gram-negative pathogens modify their lipid A structures to develop resistance against cationic antimicrobial...
This $540,818 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at Columbia University on the interdependency of chemical, structural, and physiological heterogeneity in Pseudomonas aeruginosa biofilms. The project aims to investigate how biofilm and infection-site conditions impact P. aeruginosa's use of lactate as a carbon source, and how the bacteria tolerate their own production of cyanide, a virulence factor. The research will employ advanced techniques like imaging mass spectrometry and live microscopic biofilm analysis to address questions about metabolic pathway modulation, spatial patterning regulation, and the effects of biofilm microanatomy on physiology. The award period runs from Aug 2025 to Jul 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.8k | 8/5/25 |