This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut microbiome. The goals are to discover highly active, secreted, and stable PG-degrading enzymes (Aim 1) and develop genetic tools...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $233,250 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of North Carolina at Chapel Hill. The grant, which runs from May 13, 2025 to April 30, 2027, will support research to develop a novel platform for genetically modifying specific bacterial species within complex gut microbiomes. The key objectives are to engineer self-recirculating, non-replicating...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $242,310 to Duke University to investigate the mucin utilization capabilities of the gut microbe Akkermansia muciniphila. The funded research aims to identify the genes and biological mechanisms that enable A. muciniphila to thrive within the gastrointestinal mucin layer by accumulating and metabolizing mucin, which is...
This $206,615 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the mechanisms by which the gut bacterium Phocaeicola vulgatus (PVU) colonizes the mammalian gut. The research aims to identify new strategies PVU uses to effectively colonize the gut, including defining the roles of a specific operon in PVU physiology and gut colonization ability. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $597,904 to the University of Wisconsin - Madison to conduct research on the role of the human microbiome and its interactions with host genetics in childhood asthma. The research aims to: 1) detect host genome-wide associations with the infant microbiome, 2) identify genotype-microbiome interaction effects on...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,140,912 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the University of North Carolina at Chapel Hill. The 5-year grant, effective from August 1, 2024 to July 31, 2029, will support research to understand host-microbiome coevolution and genetic variation in immunity using an insect model system. The research program takes advantage of the pea aphid, an insect that reproduces...
This Project Grant award, totaling $891,678.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award will fund a project at the Scripps Research Institute in La Jolla, CA focused on using chemoproteomic and functional analysis methods to identify microbiota bile acid-protein targets and characterize their mechanisms of action on host immunity. The goal is to better understand how...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, provides $395,701 to the University of Texas at Austin over a 5-year period from June 1, 2025 to May 31, 2030. The funding supports research to better understand the interactions between microbes and their animal hosts, with a focus on how microbial communities are shaped and how they affect the health of their hosts,...
This Project Grant award of $242,310, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at Weill Medical College of Cornell University aimed at understanding how the commensal microbiome interacts with the developing immune system in early life. The research seeks to elucidate the mechanisms by which select commensal bacteria are trafficked to the thymus, leading to the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine the mechanism by which host genetics directly influences the intestinal population of Lactobacillus murinus, a prominent gut microbiome member. The $438,608 award to the University of Chicago will fund an interdisciplinary approach spanning immunology, microbiology, and genetics to study this host-commensal interaction using a murine model developed to eliminate environmental factors. The project aims to provide an experimental platform to identify and investigate other host genetics-driven host-commensal relationships. The award period runs from July 18, 2024 to February 28, 2027.