The federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $711,808 to Yale University to support a research project titled "Tracking Brain Dynamics of the Acute Stress Response and Neurocognitive Mechanisms of Chronic Alcohol Consumption" over the period of Sep 1, 2024 to Aug 31, 2029. The key objectives of this project are to: 1) Develop and validate machine...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $545,282 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Colorado-Denver to study neural mechanisms associated with emotion regulation and alcohol cue reactivity during early abstinence from alcohol use disorder (AUD). The 5-year project aims to determine how neural function related to cognitive reappraisal and alcohol cue processing changes across early AUD treatment, and whether...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $581,869 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Kentucky Research Foundation. The grant will fund a rigorous 4-year crossover study to translate preclinical findings on the role of glucocorticoid receptors in alcohol use disorder (AUD) to humans. The study will use the selective glucocorticoid receptor antagonist PT150 to examine its effects on stress-induced and alcohol-induced...
This $498,121.57 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will support research to investigate the neural mechanisms that drive maladaptive coping strategies and subsequent alcohol use following exposure to stress. The principal investigator will utilize an animal model to study how dysfunction in the corticolimbic circuitry, specifically the prelimbic cortex and basolateral amygdala, contributes...
This federal Project Grant award of $701,135 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will fund research to characterize brain-periphery cortisol dysregulation in alcohol use disorder (AUD). The research will use a novel radiotracer and PET brain imaging to measure the availability of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the brains of...
This federal Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a study to identify novel transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research team at Yale University will perform a postmortem, multi-omic analysis of brain tissue samples from 341 subjects, including those with AUD,...
This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) program, aims to enhance the understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The $1,373,036 award will fund research utilizing cutting-edge wearable biosensors and advanced artificial intelligence (AI) methodologies to develop real-time predictive models that can anticipate...
This $180,360 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research into the role of the neuropeptide somatostatin (SST) in regulating post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) comorbidity. The research aims to apply a multidisciplinary approach, including in situ hybridization, ex vivo electrophysiology, chemogenetics, and viral gene...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...
This Cooperative Agreement award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $999,393 in funding to Stress Therapeutics, Inc. for IND-enabling studies of a novel therapeutic candidate to address alcohol use disorder (AUD). The goal is to advance the development of a first-in-class treatment for chronic management of pathological hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, a key driver of AUD....
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $275,171.12 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) on July 24, 2024. The grant will support a clinical neuroscience study to understand stress coping mechanisms in individuals with Alcohol Use Disorder (AUD) compared to matched controls. The research aims to objectively assess chronic stress and examine dynamic functional connectivity within the brain's stress coping network using fMRI neuroimaging. The findings are expected to advance the translational impact of research on the stress neurocircuitry in AUD and contribute to the grantee's development as an independent clinical and translational neuroscientist in this field.