This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA Program 93.173 "Research Related to Deafness and Communication Disorders," provides $429,000.00 to the University of Colorado-Denver to establish human lingual organoid models as a platform for studying taste bud function and perturbations. The key objectives are to: 1) validate and characterize circumvallate papillae samples from male and female human donor tissue...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA program "Research Related to Deafness and Communication Disorders" (93.173), will fund research to pinpoint the location and molecular signature of SOX10+ taste bud progenitor cells in von Ebner's glands, and investigate the regulatory role of the SOX10 transcription factor in taste bud cell differentiation. The $377,681 award, effective June 1, 2025 through...
This federal Project Grant award of $781,703, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders", supports research to better understand sensory development in human cochlear organoids. The goals are to define the developmental trajectories of key sensory cell types, test methods to increase the number of hair cells, and accelerate the maturation of hair cells and sensory...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a Project Grant under the CFDA 93.173 "Research Related to Deafness and Communication Disorders" program to The Regents of the University of Colorado (CU) in the amount of $1,018,155. The grant, with an award date of August 19, 2024 and an ultimate completion date of July 31, 2027, will support a research project titled "Neocortical Microarchitecture of Executive Function Using Large-Scale...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under CFDA program 93.173 "Research Related to Deafness and Communication Disorders", provides $1,354,376 to Duke University to conduct research aimed at defining the mechanisms driving olfactory neuronal homeostasis and dysfunction in humans. The experiments proposed will identify organized patterns of gene expression in olfactory neurons isolated from human biopsies, and assess...
This federal Project Grant award of $1,128,268.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award will support research led by President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the relationship between experience-dependent transcriptional adaptation and olfactory function in the peripheral olfactory...
This Project Grant award of $149,804.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 - Research Related to Deafness and Communication Disorders supports research to understand how inhibitory circuits in the olfactory system shape sensory responses. The project aims to delineate the functional organization of inhibitory circuits in the olfactory bulb and how inhibition manifests in neurons that transmit sensory information to higher...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $379,862 to the University of Georgia Research Foundation, Inc. to conduct research on the regulation of connective tissue in the cell renewal of mature taste buds. The key objectives are to investigate whether the neural crest-derived connective tissue cells in the core of...
This federal Project Grant award of $702,560 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the NIDCD Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research by Brandeis University and a sub-award to Harvard University on the mechanisms of gustatory receptor (GR) function and ligand recognition in invertebrates. The key goals are to: Probe the mechanisms controlling ligand sensitivity and specificity in the GR43A...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 "Research Related to Deafness and Communication Disorders" program, supports research to identify the progenitor cell population that maintains the circumvallate papilla (CVP) and von Ebner's gland (VEG) epithelium. The key objectives are to:
Use genetic barcoding and single-cell RNA sequencing to determine the lineage relationships of the SOX9+ progenitor population across the CVP and VEG complex.
Generate organoids from LGR5+, SOX9+, and LGR5+/SOX9+ cells to assess if their expression patterns restrict CVP and VEG lineage production, and determine if SOX9+ cells are truly multipotent when LGR5+ cells are ablated.
The total award amount is $111,697 with a performance period from December 15, 2024 to August 31, 2027. The work is being conducted by the University of Colorado-Denver, a major research university that has extensive experience managing federal grants and contracts.