Project Grant R21DC022075

Award Date 8/1/24
Completion Date 7/31/26
Dollars Obligated $429K
Federal Grant Program
93.173
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
Similar Awards
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173, "Research Related to Deafness and Communication Disorders", provides $111,697 to the University of Colorado-Denver to conduct research on identifying SOX9 as a marker of multipotent progenitors in the circumvallate papilla (CVP) and von Ebner's gland (VEG) to better understand the maintenance of the CVP/VEG epithelium. The research aims to determine...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to define the spatial distribution and molecular signature of SOX10+ taste bud progenitor cells within von Ebner's glands, as well as investigate the regulatory role of the SOX10 transcription factor in the differentiation of these progenitors into taste bud cells. The $377,681 award, with a...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will fund research to investigate the regulation of connective tissue in the cell renewal of mature taste buds. The University of Georgia Research Foundation, Inc. was awarded $379,862 for this 2-year project running from September 2024 to August 2026. The research aims to examine how...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders" provides $781,703 in funding to Trustees of Indiana University (doing business as Indiana University Indianapolis) for the project "Sensory Development in Human Cochlear Organoids". The project aims to better understand the genetic regulatory network underlying sensory cell...
This Project Grant award of $767,494 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports the development of human induced pluripotent stem cell-derived inner ear organoid platforms for modeling and treating genetic hearing and balance disorders. The key objectives are to: 1) Establish and optimize 3D inner ear organoid systems from patient-derived stem cells, and 2) Test CRISPR/Cas9-based gene...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $702,560 to Brandeis University to conduct research on gustatory receptors (GRs) in invertebrates. The key objectives include: 1) probing the mechanisms that control ligand sensitivity and specificity in the GR43A family of sugar receptors, 2) assessing how alternative isoforms of the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 Research Related to Deafness and Communication Disorders program, will support research to elucidate the specific mechanisms underlying persistent smell and taste disturbances in patients recovering from COVID-19. The $653,547 award to Brigham & Women's Hospital will fund a 5-year study to define the phenotype and role of infiltrating immune cells in driving...
This federal Project Grant award, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will fund research to investigate alterations in gustatory neuron innervation and function over the course of chemotherapy treatment. The $200,410 grant, awarded on June 13, 2024, will support a study to determine the timeline of gustatory fiber recovery after cyclophosphamide treatment...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) provides $682,219 to Duke University to conduct research towards understanding the molecular biology of human olfaction in health and disease. The key products and services to be delivered under this award include: Establishing the axes of transcriptional variation in human olfactory sensory neurons...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA program "Research Related to Deafness and Communication Disorders" (93.173), will provide $299,866 in funding to the University of Colorado-Denver from August 1, 2024 to July 31, 2029. The goal of this award is to train future clinician scientists in otolaryngology-related research through an integrated research experience for medical students and otolaryngology...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) provides $429,000 to establish human taste organoid models. The University of Colorado-Denver will develop lingual organoid lines from circumvallate papillae (CVP) biopsies obtained postmortem from organ donors. This will involve validating and characterizing the CVP samples, optimizing protocols to reliably produce human taste receptor cell-replete organoids, and conducting single-cell RNA sequencing to profile the cell populations. The goal is to create a human in vitro model system to study the impact of drugs and pathogens on taste homeostasis, as results from mouse models may not accurately reflect taste perturbation in patients. The award period runs from August 1, 2024 to July 31, 2026.

Generated 6/10/25, 5:50 AM