This $564,134.00 Project Grant was awarded on January 1, 2025 by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant supports scientific investigations by President And Fellows Of Harvard College Office Of Research Administration Division, doing business as Harvard Medical School, to characterize the relationship between experience-dependent transcriptional adaptation and olfactory function in the olfactory system.
The research aims to 1) combine single-cell sequencing, functional imaging, and spatial transcriptomics to understand how olfactory sensory neuron-specific transcriptional profiles relate to acute odor-driven neural responses, 2) elucidate the signaling and transcriptional mechanisms that couple olfactory sensory neuron activity to long-term changes in gene expression patterns, and 3) assess the impact of environment-dependent changes in peripheral odor codes on odor perception and behavior. These efforts are expected to reveal how odor information is translated into adaptive patterns of gene expression and how these patterns influence olfactory processing, which is essential for a comprehensive understanding of olfactory system function.
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