This federal Project Grant award of $390,687 was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), to New York University (NYU) for a research project titled "CRCNS: MULTIREGIONAL COMPUTATIONS FOR VALUE-BASED DECISION-MAKING". The project aims to characterize how the orbitofrontal cortex (OFC), dorsal striatum (DSTR), and basolateral amygdala (BLA) brain regions interact to support belief updating and...
This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
This federal Project Grant award for $188,995.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research at the University of Pittsburgh focused on understanding, preventing, and treating substance use disorders. The project aims to develop novel interventions, explore neuroscientific mechanisms of addiction, and improve treatment strategies. The...
This federal Project Grant award of $650,250 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to investigate the neural mechanisms underlying motivational and cognitive deficits associated with opioid withdrawal. The project aims to uncover the role of dopamine and acetylcholine signaling, as well as the activity of striatal projection neurons, in mediating withdrawal-induced reductions in motivation and...
This $1,672,696 project grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to identify the computational and neurophysiological mechanisms underlying the interplay between craving and decision-making in cannabis use disorders. The project will deploy a paradigm to assess craving and decision-making across two independent samples of cannabis users (online: n=1,000; in-person: n=100) and implement a joint modeling...
This federal Project Grant award of $811,112 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the network and circuit dynamics underlying dopaminergic control of sudden insight learning. The principal investigator and research team at the University of California, San Francisco (UCSF) will use a combination of large-scale two-photon calcium imaging, high-density electrophysiology, dopamine sensor fiber...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,351,034 to the University of Alabama at Birmingham (UAB) to study the role of somatostatin-expressing interneurons in the prelimbic region of the rodent medial prefrontal cortex and their involvement in natural and drug reward seeking behaviors. The award, with a project period from Apr 15, 2025...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
This federal Project Grant award of $152,324.00 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, supports research under the Drug Use and Addiction Research Programs (CFDA 93.279). The project, titled "RHYTHMS IN CHOLINERGIC INTERNEURON ACTIVITY MEDIATE DRUG-TAKING BEHAVIORS", seeks to investigate the correlation between circadian rhythms and the intrinsic properties and activity of cholinergic interneurons in the nucleus accumbens, and their...
This $105,076 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the neurocomputational basis of effort-based decision making (EBDM) in individuals with tobacco use disorder, tobacco and opioid use disorder, and healthy controls. The award will support research to characterize the neurocomputational basis of EBDM during a smoking cessation attempt. The project will computationally model effort-based choice behavior to assess differences in cost-benefit analyses for goal-directed motivation and behavior between the study groups. The award was granted to Wake Forest University Health Sciences, a private, non-profit academic medical center, and will be conducted from December 1, 2025 to December 31, 2027.