This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $149,284 to the University of Washington to investigate the role of specific neuron subpopulations in the prefrontal cortex in regulating drug-seeking behavior. The project aims to use combinatorial viral approaches and techniques like fiber photometry and chemogenetics to characterize how chronic heroin self-administration alters the...
This $373,300 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the role of the nucleus accumbens, a key brain region involved in reward learning and addiction, in discriminating between cues associated with rewards versus neutral cues. The research aims to enhance understanding of the neural dynamics underlying selective conditioned responses to reward-predictive...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $314,225 to the University of Washington to explore the unique neurobehavioral profile of sequential opioid-stimulant polysubstance use disorders. The study aims to 1) define the behavioral patterns of dual opioid-methamphetamine use disorders in a rodent model, and 2) map neural activation patterns within the cortico-basal ganglia-thalamic...
This federal Project Grant award of $107,948 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the effects of concurrent chronic stress and cocaine self-administration on medial prefrontal cortex (mPFC) microglia and drug choice behavior. The research will be conducted by The Medical College of Wisconsin, Inc. from December 2024 through April 2028. The goal is to develop a better understanding of the...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $162,672 to the University of California, Los Angeles (UCLA) to conduct research on the role of dopamine projections to the amygdala in goal-directed and habit learning. The research aims to characterize the function of dopaminergic pathways from the ventral tegmental area to the basolateral and central amygdala, and their necessity for...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to support research aimed at dissecting the mechanisms of dopamine transmission and their roles in reward-related behaviors. The project, titled "Dissecting Modes of Dopamine Transmission and Their Roles in Reward Related Behaviors," will be conducted by the University of Colorado-Denver over a 3-year period from...
This is a federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,838,237 award supports research to investigate how chronic stress influences the neural circuits controlling goal-directed behavior versus habit formation. The project aims to expose the specific amygdala-striatal pathways through which chronic stress can promote premature habit learning, which is a key mechanism underlying substance use...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Federal Grant Program "Drug Use and Addiction Research Programs" (CFDA 93.279), supports research into the glucocorticoid receptor (GR) as a neuromolecular mechanism regulating impulsivity and reward sensitivity within the prelimbic cortex (PRL) to nucleus accumbens core (NAcc) pathway. The $127,635 award to the Regents of the University of Michigan aims to employ transgenic rat models with conditional...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $800,617 to support the development and validation of neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience related to substance use disorders (SUDs). The key products and services to be delivered under this 5-year award include: 1) Using machine learning and fMRI data to create a cross-validated...
This federal Project Grant award for $220,340 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research investigating the role of microglia as a mechanism of medial prefrontal cortex dysfunction following adolescent cannabis exposure. The two-year project, awarded to Washington State University starting in September 2024, aims to determine whether microglial activation is necessary for the cognitive flexibility deficits...