Project Grant R01DA058374

Award Date 9/15/24
Completion Date 5/31/29
Dollars Obligated $611K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
California, USA
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The research aims to uncover the neural circuits through which chronic stress leads to a shift from goal-directed to habitual behaviors, which can contribute to the development of substance use disorders and other mental illnesses. Using advanced techniques like optical neuronal activity monitoring, microendoscopic calcium imaging, and pathway-specific chemogenetic manipulations, the project will examine the opposing roles of two amygdalar-striatal pathways in goal-directed and habit learning, and how chronic stress disrupts this balance to promote harmful habits. The findings are expected to provide critical insights into the neural mechanisms underlying stress-induced pathological habit formation, informing future efforts to understand and treat substance use disorders and related mental health conditions.

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