This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $121,364 to the University of California, Los Angeles (UCLA) to conduct critical investigation into the neural circuitry that supports goal-directed and habit learning. The research will use advanced techniques such as optogenetic manipulation and in vivo fiber photometry to study the role of dopaminergic projections from the ventral...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, is providing $275,171.12 to the University of California, Los Angeles (UCLA) to conduct research on the neural mechanisms that underlie the association between stress and alcohol use disorder (AUD). The key objectives of the study are to: 1) objectively assess chronic stress in individuals with AUD compared to matched controls,...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, will support research into the neurocircuitry underlying motivated reward-seeking behavior as a coping mechanism for stress. The $606,029 award, effective August 1, 2024 through July 31, 2025, will be administered by the University of Massachusetts Medical School. The key objectives are to investigate how sub-populations of neurons in the medial...
This Project Grant award in the amount of $235,816 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the role of the basolateral amygdala in learning inhibitory associations about reward availability. The key goals are to determine the temporal dynamics of basolateral amygdala activity during the development of these inhibitory associations, assess whether basolateral amygdala activity is necessary and...
This federal Project Grant award, totaling $346,911, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award, valid from August 15, 2024 to July 31, 2026, will support a cross-species study to identify neurocognitive, genetic, and socioenvironmental risk factors for substance use disorders (SUDs). The key objectives of the project are to: 1) determine how early life environment influences neurocognitive development...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to advance the understanding of the role of the G9A/GLP chromatin modifying enzymes in the development of addictive behaviors. The $272,395 award, with a performance period from April 2025 to March 2027, will enable researchers at the University of California, San Francisco (UCSF) to: 1) identify specific surfaces on the G9A and GLP...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $242,310 in funding to The Medical College of Wisconsin, Inc. to conduct research on the involvement of GQ signaling in the mobilization of 2-arachidonoylglycerol (2-AG) by corticosterone in the prefrontal cortex, and its potential impact on stress-related relapse in substance use disorder. The research aims to enhance understanding of...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $498,121.57 to the University of New Mexico to investigate the neural mechanisms underlying stress coping and subsequent alcohol use. The key objectives are to: 1) examine how dysregulation in the corticolimbic circuitry, specifically between the prelimbic cortex and basolateral amygdala, may drive maladaptive...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on investigating a specialized serotonergic-septohippocampal circuit that may influence the vulnerability for relapse in substance use disorders. The $254,250 award, spanning from July 2024 to June 2026, will support the delineation of the intrinsic properties and transmission interactions of a novel neuronal cell type (LSI-R2P) that is modulated...
The U.S. National Institute on Drug Abuse (NIDA) awarded a $107,948 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical College of Wisconsin, Inc. The grant, titled "CONCURRENT CHRONIC STRESS AND COCAINE SELF-ADMINISTRATION: UNDERSTANDING EFFECTS ON MPFC MICROGLIA AND DRUG CHOICE BEHAVIOR," commenced on December 3, 2024 and is scheduled for completion by April 30, 2028. The project aims to investigate the effects of concurrent chronic stress...