This $898,660 project grant from the National Cancer Institute, part of the Department of Health and Human Services, will fund research into the role of SWI/SNF chromatin remodelers in homologous recombination and genome stability. The grant is awarded under the Cancer Cause and Prevention Research program (CFDA 93.393), which supports identification of cancer risks and mechanisms for prevention. The Midwestern University project will further define the mechanisms by which BRG1 and BRM stimulate...
This Project Grant award from the National Cancer Institute's Cancer Research Manpower (CFDA 93.398) program provides $148,568.00 to St. Jude Children's Research Hospital Inc. to investigate the mechanism by which a gene essential for rhabdoid tumor viability regulates chromatin function. The project aims to gain mechanistic insights into the interplay between the SWI/SNF chromatin remodeling complex and the polycomb complex, which is disrupted in rhabdoid tumors. The research will use molecular...
This $126,311 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at Harvard Medical School to investigate the mechanisms by which heterochromatin regulates transcriptional gene silencing. The 3-year award, which commenced on July 15, 2024, aims to elucidate the specific functions of the heterochromatin protein 1 (HP1) complex in inhibiting RNA polymerase II activity and...
This $780,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to develop new computational tools and methodologies for accurately predicting the functional effects of genetic mutations, with a focus on the chromatin remodeling enzyme SMARCA4. The goal is to improve the interpretation of human genetic variations and enhance the ability to diagnose and treat diseases,...
This $127,049 Project Grant award from the National Cancer Institute's Cancer Research Manpower (CFDA 93.398) program will support research conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the functional and spatial properties of tumor-specific, tumor-infiltrating CD8 T cells. The research aims to better understand the determinants of T cell responses against tumors, with a focus on assessing the required diversity of T cell...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting research on epigenetic regulation of transcriptional programming at Brigham & Women's Hospital. The $2,720,800 award from July 2024 to May 2029 will fund investigations into how chromatin regulators and transcription factors collaborate to enable the remarkable developmental transitions of a single fertilized egg into a...
This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $445,000 to the Dana-Farber Cancer Institute, Inc. (DFCI) to fund research on the molecular mechanisms of DNA double-strand break repair by homologous recombination. The research aims to elucidate the fundamental processes underlying this critical DNA repair pathway, which is often defective in cancers like breast and...
The federal Project Grant award R15GM151701 in the amount of $455,630.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to gain a mechanistic understanding of how cells dynamically regulate and utilize different forms of the SWI/SNF chromatin remodeling complex in response to environmental stimuli, specifically hypoxia. The research aims to define the composition...
This Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to define the roles of sequence-non-specific DNA-binding domains in the assembly and function of the mammalian SWI/SNF chromatin remodeling complex. The $122,408 award to President and Fellows of Harvard College aims to: a) determine how these DNA-binding domains contribute to proper SWI/SNF complex assembly and biochemical integrity; b) assess their impact on SWI/SNF complex catalytic activity and nucleosome remodeling; and c) evaluate their influence on SWI/SNF genome-wide targeting and DNA accessibility in human cell line models. This research will elucidate key mechanisms governing chromatin remodeling complex activities in normal cellular processes and human diseases, including cancers and neurodevelopmental disorders where SWI/SNF genes are frequently mutated.