Project Grant F30DE034308
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- This $249,000 federal Project Grant, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to identify cell fate determination processes specific to salivary cell populations in order to advance regenerative therapies. The principal investigator at Rutgers, The State University of New Jersey will conduct studies to understand the normal developmental processes and transcriptional and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $273,009 Project Grant to Virginia Commonwealth University (VCU) to characterize a conserved streptococcal membrane protein affecting manganese utilization. The project aims to determine the crystal structure and functional role of this membrane protein, hypothesized to be an acyltransferase that incorporates polyunsaturated fatty acids...
- This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project focused on investigating the biogenesis and localization of gingipains - critical virulence factors of the oral pathogen Porphyromonas gingivalis. The $358,823 grant, awarded to Loma Linda University, aims to expand the understanding of gingipains' hemagglutinating/adhesive properties and the...
- This Project Grant award of $174,418.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The objective is to understand how this direct sensory innervation of the submandibular glands by trigeminal neurons contributes to the regulation of saliva production and...
- This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), funds research to investigate the association between the oral microbiome and biomarkers of Alzheimer's disease and related dementias (ADRD), as well as mid-life cognitive function. The $332,787 award, granted on August 14, 2025, will leverage data from the High School & Beyond (HS & B:80) cohort study...
- The federal Project Grant award of $401,500 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research at Louisiana State University Health Sciences Center-Shreveport (LSU Health Sciences Center-Shreveport) to investigate fundamental aspects of the innate immune response to SARS-CoV-2 within the salivary gland. The 2-year project aims to explore how antigen presentation mechanisms may shape or...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
- This Project Grant award, titled "Defining the Role of Tissue-Resident Macrophages During Salivary Gland Morphogenesis", was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $100,676 award to the Icahn School of Medicine at Mount Sinai will fund research to determine the functional contribution of tissue-resident macrophages in regulating salivary gland development, including...
The federal Project Grant award of $110,676.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine the binding partners and functional role of the protein Zymogen Granule 16B (ZG16B) in human salivary gland cells. The research aims to quantify changes in the concentration of salivary ZG16B in healthy individuals and those with oral inflammatory conditions such as chronic graft versus host disease and oral lichenoid lesions. The project will be conducted by the Trustees of Indiana University at the Indiana University Indianapolis campus from December 1, 2025 to June 30, 2027. The findings may identify ZG16B as a potential biomarker for diagnosing oral tissue damage through non-invasive saliva collection.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/28/25 | ||
| Not listed | $0 | 7/28/25 | ||
| Not listed | $55.3k | 6/25/25 | ||
| Not listed | $55.3k | 6/25/25 |