This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This federal Project Grant award for $634,617, awarded by the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs, will support research on the neural basis of the transition from goal-directed to habitual behavior. The primary objectives are to: 1) validate a novel "volitional engagement" behavioral paradigm using techniques like optogenetics and outcome devaluation, 2) monitor and manipulate neural circuits in the...
This three-year, $4.93 million project grant from the National Institute on Drug Abuse will fund research into odor trail tracking behavior in mice. The grant supports three principal investigators at Harvard University who will study the algorithms and neural circuits underlying active sensation and continuous decision-making during this olfactory navigation behavior. The researchers will use behavioral, physiological, molecular and computational methods across three aims. In Aim 1, they will...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant...
This Project Grant award of $142,656 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to understand the neural mechanisms underlying craving and its impact on decision-making in food addiction. The award will fund a study that induces craving through multisensory food cues and examines how craving differentially affects subjective value computations for craved and non-craved foods in individuals with and without...
This Project Grant award, valued at $629,844.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will support research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The research will use bidirectional optogenetics, in vivo electrophysiology and photometry, and quantitative behavioral...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate the role of the glucocorticoid receptor (GR) as a neuromolecular mechanism regulating impulsivity within the prelimbic cortex-nucleus accumbens pathway. The total award amount is $127,635, with a project period from June 17, 2025 to December 31, 2025. The research, conducted by the Regents of the University of Michigan,...