Project Grant DP5OD039406
- This $568,177 federal Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on how centrioles, the core structures of centrosomes, control mammalian development. The University of California, San Francisco (UCSF) is the primary awardee and will leverage advanced techniques like centrosome affinity capture mass spectrometry and pan-expansion microscopy to investigate how centriole defects...
- This $556,295 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance scientific understanding of cardiac pacemaking and sinus node dysfunction (SND) through research on "conditional pacemaker cells" within distinct specialized pacemaker cell subpopulations. The project will leverage advanced optical mapping technology to directly visualize pacemaking activities within these specialized cell...
- This Project Grant award, valued at $150,876.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Regents of the University of California, doing business as the University of California, Berkeley. The award supports research to elucidate how bone morphogenetic protein (BMP) signaling regulates the development and differentiation of cardiac neural crest cells, which are critical for proper heart formation. The study will leverage in...
- This $681,393 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the regulation and function of multicellular calcium signaling in organ growth and regeneration. The research aims to elucidate the principles governing cell-cell communication and calcium ion (Ca2+) signaling dynamics during organ development, with the long-term goal of programming cellular...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
- This federal Project Grant award of $621,546.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), focuses on observing the single molecule dynamics of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) under both normal and disease-associated conditions. The primary objectives are to: 1) Engineer a single-walled carbon nanotube field effect transistor (SWNT FET) system to record PKA-C single molecule...
- The University of California, San Diego (UCSD) was awarded a $788,513 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study the mechanisms underlying the maintenance of cardiac chamber identity in zebrafish. The research aims to elucidate the genetic pathways that reinforce ventricular cardiomyocyte identity, as ventricular myocardium harbors considerable plasticity and can transform to acquire atrial traits under certain...
- This Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $327,019 award supports research to elucidate how cell motion and mechanical forces affect intercellular signaling and cell fates during embryonic development and tissue formation. The University of California, San Diego (UCSD) is conducting this 5-year project to develop biophysical principles and data-driven methods...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $1 to the Regents of the University of California, San Francisco (UCSF) to explore the changing patterns of cardiac calcium signaling during embryonic heart development. The research aims to define the precise rules governing how cellular calcium dynamics map to downstream developmental processes, in order to better understand the mechanisms underlying a robust heartbeat. UCSF will leverage advanced imaging and optogenetic techniques to investigate these high-dimensional calcium signaling patterns in intact zebrafish embryos. The project period runs from August 6, 2025 to July 31, 2030 and is focused on advancing scientific understanding of the instructive role of calcium signaling in cardiac maturation, with potential implications for both normal development and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/15/25 | ||
| Not listed | $0 | 8/13/25 | ||
| Not listed | $1 | 8/6/25 |