Project Grant DP5OD039380
- This Project Grant award, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), will fund a research initiative to develop a cell type-specific atlas of transcription factor-regulatory element connectivity across human tissues. The $315,060 award will integrate single-cell ATAC-seq data from the GTEx and HuBMAP Common Fund projects and utilize deep learning models to establish this regulatory protein binding atlas. The project aims to...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
- The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
- This federal Project Grant award of $491,739 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project to determine the molecular mechanisms underlying the evolution of transcriptional circuits in yeast. The 5-year project, which runs from September 1, 2025 to August 31, 2030, will utilize experimental approaches such as mutant construction, genome-wide transcriptional profiling, and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $415,252 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports a 5-year research project to develop a predictive understanding of transcriptional regulation in early embryonic development using the fruit fly Drosophila melanogaster as a model organism. The...
- This federal Project Grant award of $2,203,340.00, awarded on September 20, 2025 by the National Institute of General Medical Sciences (NIGMS), is part of the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research to define the mechanistic rules governing how transcription factors (TFs) bind to chromosomal DNA within compacted chromatin. The goal is to systematically dissect the factors required for initial and sustained TF binding to...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This $292,727 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports a research project by The Broad Institute, Inc. to discover novel regulators of 3D genome organization. The project aims to leverage large-scale genomic datasets to predict and experimentally validate new trans-acting factors that regulate chromatin interactions and genome architecture. By applying deep neural network models to in silico genetic...
- This $1,079,254 National Science Foundation project grant supports research investigating mechanisms of RNA polymerase II transcription and regulation using single molecule fluorescence techniques at the University of Colorado Boulder from March 2023 through February 2027. The research will study the assembly and disassembly of key protein complexes involved in early transcription stages using microscopy to observe individual molecules. Specifically, the research will investigate how the human...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
This Project Grant award from the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) will support the development of novel high-throughput approaches to discover and dissect human transcriptional protein interactions. The $350,460 award to the University of California, San Francisco aims to generate a comprehensive matrix of 106 proximities between human transcriptional effector domains and cofactors, providing crucial insights into the molecular mechanisms driving transcriptional regulation. The project will leverage expertise in high-throughput approaches, biophysics, and quantitative cell biology to enhance understanding of transcription factors and their role in human development, health, and disease. This research could stimulate the development of new therapeutics targeting historically undruggable transcription-associated protein interactions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.5k | 8/5/25 |