Project Grant DP2GM164659
- The Washington University Office of Sponsored Research Services Division in St. Louis, Missouri was awarded a $1,399,500 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant, which began on September 1, 2023 and runs through August 31, 2026, will fund a research project aimed at uncovering the regulatory mechanisms underlying gene expression and how mutations in transcription factor regions can lead to pathological changes...
- This federal Project Grant award of $427,571.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project titled "Maintenance of Cellular Memory During Replication" at the University of Colorado-Denver. The project aims to uncover the molecular determinants of cellular identity and how chromatin states are regulated across the cell cycle. Key objectives...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
- This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This $1,588,500 federal Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) was made to the University of Washington on September 12, 2025. The grant funds a research project titled "LEARN FROM THE ERRORS AT THE START OF LIFE: DISSECT CELLULAR FITNESS THROUGH DYNAMICS OF CHROMOSOMAL INSTABILITY IN EMBRYOGENESIS." The project aims to establish an in vitro model system using embryonic and extraembryonic stem cell lines to...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $380,587 to The Johns Hopkins University from January 1, 2025 to December 31, 2029. The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular responses to perturbations at single-cell resolution. The research will focus on understanding...
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
- This Project Grant award of $394,434 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research program entitled "Decoding Epigenetic Adapters of Cell State" at the University of Alabama at Birmingham (UAB). The project aims to mechanistically interrogate the epigenetic contribution to cellular identity by examining the regulation of RNA polymerase II checkpoints, defining how gene body...
- This federal Project Grant award, valued at $442,750.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the regulation of canonical and non-canonical substrates of histone lysine methyltransferases. The research aims to address key knowledge gaps in understanding the mechanisms of active chromatin inheritance and systematically investigating the importance of...
This Project Grant award of $1,399,500.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports time-lapse epigenome profiling research at The Washington University in Missouri. The goal is to observe spatiotemporal changes in chromatin-mediated gene regulation that are associated with successful cellular reprogramming, and to functionally test whether these epigenetic events can lead to more efficient induced cell fate conversion outcomes. The research aims to advance the understanding of epigenetic factors that influence the efficiency of cellular reprogramming, with potential applications in the development of more reliable cell-based therapies. The project period runs from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 7/24/25 |