Project Grant DP2HD121941
- The Project Grant award titled "Asymmetric RNA Segregation in Neural Stem Cells" was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $392,004 grant will support research at the University of Washington to identify and characterize asymmetrically segregating RNA molecules in fly neural stem cells, with the goal of understanding how RNA partitioning contributes...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This $2,624,970 federal Project Grant, awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), aims to construct the first-ever foundational in silico (computational) model of whole-embryo mouse embryogenesis. The project will leverage cutting-edge sequencing technology and machine learning techniques to establish a large-scale 3D multi-omics cell atlas of mouse embryogenesis from embryonic day 6.5 to 16.5, involving a total of 50 million...
- This Project Grant award of $1,399,500.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports time-lapse epigenome profiling research at The Washington University in Missouri. The goal is to observe spatiotemporal changes in chromatin-mediated gene regulation that are associated with successful cellular reprogramming, and to functionally test whether these epigenetic events can lead to more efficient induced cell fate conversion outcomes. The...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $133,401 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Fred Hutchinson Cancer Center, located in Seattle, WA. The grant, awarded on September 1, 2025, is intended to develop computational models that can identify the sequence of changes a cell undergoes during differentiation and maturation, and compare changes in gene expression...
- This Project Grant award from the U.S. Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $1,148,000.00 in funding to the Regents of the University of California, San Francisco (UCSF) to pioneer approaches for engineering biological error correction mechanisms. The project aims to develop generalizable systems using computationally designed proteins to achieve error correction capabilities rivaling...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The Washington University Office of Sponsored Research Services Division in St. Louis, Missouri was awarded a $1,399,500 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant, which began on September 1, 2023 and runs through August 31, 2026, will fund a research project aimed at uncovering the regulatory mechanisms underlying gene expression and how mutations in transcription factor regions can lead to pathological changes...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This federal Project Grant award for $380,540.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, supports research to investigate the relationship between DNA methylation and microRNAs during early human embryonic stem cell lineage specification. The research program seeks to dissect the early cell fate changes due to epigenetic regulation using omics technologies, cell imaging, and transcriptional regulator...
This $1,588,500 federal Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) was made to the University of Washington on September 12, 2025. The grant funds a research project titled "LEARN FROM THE ERRORS AT THE START OF LIFE: DISSECT CELLULAR FITNESS THROUGH DYNAMICS OF CHROMOSOMAL INSTABILITY IN EMBRYOGENESIS." The project aims to establish an in vitro model system using embryonic and extraembryonic stem cell lines to study the mechanisms of chromosomal instability (CIN) and tolerance in early embryogenesis. The research will address three main questions: 1) cell type-dependent intrinsic mechanisms of CIN tolerance and suppression, 2) the role of embryonic microenvironment in shaping CIN dynamics, and 3) the impact of CIN on developmental fate decisions and tissue homeostasis. The project leverages stem cell and organoid techniques along with advanced genomic and imaging tools to provide insights into the remarkable resilience of embryos to chromosomal abnormalities, with the ultimate goal of advancing the understanding of cell-type specific and context-dependent cellular fitness during early development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/10/25 |