The Washington University Office of Sponsored Research Services Division in St. Louis, Missouri was awarded a $1,399,500 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant, which began on September 1, 2023 and runs through August 31, 2026, will fund a research project aimed at uncovering the regulatory mechanisms underlying gene expression and how mutations in transcription factor regions can lead to pathological changes in gene expression. The project seeks to develop a high-resolution understanding of the role of intrinsically disordered regions in transcription factors and how they coordinate gene expression. The research will employ rational sequence design, in vitro analysis, and computational modeling to delineate the molecular basis for this process and its implications for diseases characterized by dysregulation of gene expression, such as cancer, neurodegeneration, and viral infections.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.4m | 8/25/23 |