Project Grant DP2GM164340
- The federal Project Grant award DP2GM154152, in the amount of $1,525,500.00, was provided by the National Institutes of Health (NIH) through the Trans-NIH Research Support program (CFDA 93.310). The award will support a project at Harvard Medical School to develop experimental and analytical approaches for capturing and quantifying "chemical epistasis" - the combinatorial effects of different small molecules in biological signaling and processes. The project aims to advance the...
- The federal Project Grant award of $453,750.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to President and Fellows of Harvard College (doing business as Harvard Medical School) on April 16, 2025. The grant supports the development of advanced mass spectrometry-based proteomics workflows to improve throughput, depth, and accuracy in profiling protein abundance, post-translational...
- This federal Project Grant award of $2,011,480.00 from the Department of Health and Human Services National Institutes of Health under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research by the Regents of the University of Michigan on enzyme-inspired multimetallic cooperativity. The research aims to address key questions related to how metal ion identity alters electronic structure in multimetallic active sites, how Lewis acid adducts...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $552,403 Project Grant to The Trustees of Columbia University in the City of New York. The grant, effective September 1, 2025 through August 31, 2030, will support research to develop innovative methods for the selective synthesis of functionalized amines and heterocycles from common feedstock chemicals. The research aims to address unmet needs in...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $457,500.00 under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Massachusetts Boston. The grant, with a performance period from September 17, 2024 to August 31, 2027, aims to systematically identify chemical processes and reactions that show promise when initiated under high hydrostatic pressure (HHP) conditions. The research will involve a combination of...
- This $373,117 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) supports Emory University's development of novel "bowl-shaped" catalysts for selective C-H functionalization. The research aims to transform pharmaceutical drug synthesis by enabling access to new chiral scaffolds and enhancing site-selectivity in unactivated C-H bond functionalization. Over the 5-year project period from August...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- The National Institute of General Medical Sciences (NIGMS) awarded a $892,260 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Texas at Austin. The grant, which runs from February 1, 2025 to January 31, 2030, supports the development of a family of catalytic methods for C=X/C=C (X = O, NR) and C-X/C-Y (X = Y = halide) reductive C-C couplings mediated by H2, 2-PrOH, and NaO2CH. This includes catalytic hydrogen auto-transfer reactions...
The Department of Health and Human Services National Institutes of Health (NIH) awarded a $1,516,500 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Harvard University's Office for Sponsored Programs Division. The grant, effective from September 1, 2025 to August 31, 2028, supports research to develop organic, metal-free catalysts capable of performing chemical processes traditionally enabled by transition metals. The goal is to discover strategies that use entire organic molecules or fragments as substitutes for scarce, toxic, and environmentally damaging transition metals in essential drug discovery and manufacturing reactions, such as cross-couplings. The project aims to demonstrate the ability of organic "pseudometals" to mimic and expand upon the reactivity of transition metals, ultimately enabling access to new chemical space for accelerated drug discovery and rapid construction of bioactive small-molecule agents.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/4/25 |