Project Grant R35GM158111
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded Clemson University a $312,559 project grant for the period of September 1, 2025 to August 31, 2030. The grant supports the development of new deoxygenative functionalization methods to access medicinally valuable chiral amines and fluorinated compounds from alcohols and carboxylic acids. The research aims to enable one-step, stereospecific...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $401,233.00 to Duke University to develop new catalytic selective amination methods and aminofunctionalization cascades. The goal is to streamline the creation of structurally complex and richly functionalized novel nitrogen-containing molecules from readily available starting materials, such as alkenes, dienes,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $422,569 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Vanderbilt University, effective May 1, 2025 through April 30, 2030. The funding supports the development of new reactions and reagents to generate enantioenriched organic compounds that can serve as precursors for medicinal agents and biologically active natural products. The proposed methods target the synthesis of secondary...
- This federal Project Grant award of $654,950.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a unified framework for generating oligonucleotide-based receptors (aptamers) to detect a variety of small molecule targets that are difficult to isolate using standard protocols. The research, conducted by The Trustees of Columbia University in the City of New York, will address two...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $385,298 project grant to The Research Foundation for The State University of New York (Stony Brook University) for the period of February 1, 2025 to December 31, 2029. The project aims to develop a new biomimetic organic synthesis approach that leverages rationally designed pyridoxal-5'-phosphate (PLP)-mimicking catalysts to enable open-shell radical...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This federal Project Grant award, valued at $287,488 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a multi-year research initiative to deeply understand how proteins occupy conformational ensembles to enable biological functions. The overall goal is to develop strategies to computationally design new, functional protein ensembles from scratch, with a focus on engineering protein...
- This Project Grant award of $259,966, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop new synthetic strategies to functionalize pyridine and diazine heterocycles. The goal is to introduce novel methods for directly and selectively installing a range of substituents on these heterocycles, which are widely used in medicinal chemistry. The project will explore three approaches: 1)...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $552,403 Project Grant to The Trustees of Columbia University in the City of New York. The grant, effective September 1, 2025 through August 31, 2030, will support research to develop innovative methods for the selective synthesis of functionalized amines and heterocycles from common feedstock chemicals. The research aims to address unmet needs in heterocycle synthesis and enable the streamlined installation and derivatization of nitrogen-containing molecules, which are prevalent in bioactive compounds and pharmaceuticals. The project will leverage Columbia University's expertise in areas such as quantum computing, AI, and advanced materials to advance these synthetic transformations and contribute to the fundamental understanding of carbon-nitrogen bond formation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $552.4k | 8/1/25 |