This $422,931 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research to characterize how specialized metabolites mediate interactions within the human microbiome, with the goal of understanding how these metabolite-driven community dynamics influence susceptibility to antimicrobial therapies. The research will integrate cheminformatics analysis of...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $457,500.00 under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Massachusetts Boston. The grant, with a performance period from September 17, 2024 to August 31, 2027, aims to systematically identify chemical processes and reactions that show promise when initiated under high hydrostatic pressure (HHP) conditions. The research will involve a combination of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will develop a novel micro-capsule technology to enable high-throughput analysis of millions of live cell-cell interactions in parallel. The $665,616 award to President and Fellows of Harvard College, doing business as Harvard Medical School, will establish two prototype methods to screen and map cell interactions at a scale 100-10,000...
This $148,568 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to elucidate the role of chromatin structures in genomic imprinting. The project, led by Harvard University, aims to investigate the regulatory mechanisms and functional implications of allele-specific chromatin structures in the regulation of the MEST-COPG2 imprinted domain, which is associated with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $453,750.00 to President and Fellows of Harvard College, doing business as Harvard Medical School, to develop advanced proteomics pipelines to improve depth, throughput, and accuracy of mass spectrometry-based protein analysis. The research aims to address challenges in sample preparation and data acquisition processes to...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...