Project Grant DP2GM154019

Award Date 9/6/23
Completion Date 8/31/26
Dollars Obligated $1.4M
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
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This $1,355,273 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Michigan. The grant funds the development of two complementary approaches to inhibit the production of the bacterial metabolite colibactin, which has been linked to colorectal cancer and microbiome dysbiosis.

The first approach involves enzymatic inactivation of colibactin through bacterial surface display of an anti-colibactin enzyme. The second strategy utilizes CRISPR systems to genetically inhibit the conserved colibactin biosynthesis genes in diverse colibactin-producing bacteria. Both the enzymatic and genetic inhibition systems will be delivered by genetically tractable E. coli isolates. The award period runs from Sep 6, 2023 to Aug 31, 2026.

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