The National Cancer Institute (NCI) has awarded a $400,890 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant's objective is to profile patient-specific tumor-microbiome interactions and conduct quantitative molecular analyses to elucidate microbiome-mediated modulation of immune checkpoint molecules in mismatch repair-proficient, microsatellite-stable colorectal tumors. The research team will utilize patient-derived tumor or normal organoids in a pathomimetic colorectal cancer chip model to assess the impact of tumor-microbiome interactions on immune checkpoint molecules and tumor immunotherapy responsiveness. This 3-year project, running from March 1, 2025 to February 28, 2028, aims to provide a strategic roadmap and personalized workflow to enhance immunotherapeutic effects on non-responsive colorectal tumors.
Generated 3/18/25, 2:47 AM