This $138,240 federal Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research conducted by Weill Medical College of Cornell University to define novel mechanisms by which interactions between the gut microbiota and the host immune system impact tumor growth, progression, and response to immunotherapy. The research aims to uncover two novel pathways through which the microbiota modulates anti-tumor immunity, providing new...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research program) provides $179,988 to The Leland Stanford Junior University to conduct research aimed at modulating the human gut microbiome to enhance immune responses against cancer. The research focuses on identifying bacterial genes and functions that can improve the efficacy of cancer immunotherapy, specifically immune checkpoint blockade. Key components include aggregating and analyzing metagenomic...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $626,893 in funding to the University of Texas MD Anderson Cancer Center to investigate the role of bacterial-colonized microniches within tumors and their impact on intratumoral heterogeneity and cancer progression. The research aims to: 1) Map the spatial distribution and cellular interactions of these bacterial-colonized microniches within patient tumor tissues, 2) Identify the human...
This $678,399 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program will fund a prebiotic diet intervention study at The University of Texas MD Anderson Cancer Center. The study aims to evaluate the impact of a prebiotic-enriched diet on enhancing the gut microbiome and improving immunotherapy response in patients with metastatic melanoma. The research will assess the effects of this dietary intervention on the gut...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $281,606.00 in funding to New York University School of Medicine for a 5-year research project titled "Harnessing Human Gut-Derived Bacteroides to Drive Systemic Anti-Tumor Immunity." The research aims to clarify the mechanisms by which certain gut bacteria can elicit anti-tumor immune responses in lung cancer, even in the absence of immunotherapy. The project will utilize a...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $537,985 in funding to The University of Texas MD Anderson Cancer Center to conduct research on the role of microbes in pancreatic cancer development and metastasis. The key objectives of this 5-year research project are to: Characterize the location, distribution, and functional properties of microbes within the pancreatic tumor microenvironment, including primary tumors and...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $702,748 to Weill Medical College of Cornell University to conduct research on the role of neutrophils in anti-tumor immunity and immune-related adverse events associated with T cell-based cancer therapies. The key objectives are to: Characterize the gene pathways and tumor-derived factors that define functional subsets of anti-tumorigenic neutrophils, with the goal of...
This $854,736 Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports the development of robust statistical methods for analyzing longitudinal microbiome studies. The primary grant recipient, Weill Medical College of Cornell University, will lead the effort to create a comprehensive suite of statistical tools to address key challenges in longitudinal microbiome data analysis,...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), is focused on investigating how amino acid availability impacts the function and exhaustion of tumor-infiltrating CD8+ T-cells. The $103,948 award to the Sloan-Kettering Institute for Cancer Research in New York will support two key research aims: Determining how local amino acid availability affects the proteome and translational state of exhausted...
This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) provides $654,763 to The Johns Hopkins University to conduct research aimed at understanding how the gut microbiome promotes resistance to endocrine and immunotherapies in metastatic castration-resistant prostate cancer. The key products and services to be delivered include: Defining the functional significance of microbial-derived androgens on immunotherapy effectiveness, determining...