This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is funding research to investigate the role of biomolecular condensates in bacterial adaptation and evolution. The $402,500 award to New York University aims to develop novel optical and proteomic tools to study the structure, dynamics, and interactome of these membraneless compartments in bacteria. The research will focus on...
This $410,000 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research program to uncover the molecular determinants that control the composition and assembly mechanisms of intracellular biomolecular condensates. The Trustees of Princeton University, a prestigious private research university, will leverage theoretical and computational methods, including molecular simulation,...
The National Institute of General Medical Sciences (NIGMS) awarded a $147,656 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Michigan. The grant, awarded on May 7, 2025, with an ultimate completion date of January 31, 2027, will fund research to define the mechanisms by which individual microtubules are identified and selected for specific post-translational modifications in cells. The research aims to determine how...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) aims to define the core biochemical principles that underpin the spatial and temporal regulation of biomolecular condensates, using C. elegans P granules as a model. The $396,250 award, effective from August 1, 2024 through July 31, 2029, will support a multifaceted research approach including biochemistry, cell biology, and genetics...
This federal Project Grant award for $583,698.00, funded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859), supports research to decode the rules governing coordination of the bacterial cell cycle. The project aims to: (i) define the mechanisms by which the replication initiator DnaA and the partitioning system ParABS coordinate the initiation of chromosome replication with centromere segregation, and (ii) uncover...
This $452,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program aims to develop innovative tools to dissect how nuclear speckles, membrane-less organelles in the cell nucleus, detect proteostatic stress and regulate temporal proteostasis dynamics. The research seeks to unveil the mechanisms governing the spatial and temporal coordination of various protein quality control processes, such as...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $374,595 to the Regents of the University of Michigan to develop innovative methodologies to study the complex interactions between controlled 3D nano/micro-topographies and multiple biological entities in 4D (3D space and time). The key objectives are to: (1) develop versatile 3D topographic nanopatterning tools that can accurately...
This $123,737 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting research by the Regents of the University of Michigan to advance drug discovery for protein domains containing intrinsically disordered regions. The award, effective October 1, 2024 through April 30, 2025, will enable the University of Michigan to leverage its expertise in molecular biology, genetics, and...
This $1,003,736 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research will focus on two key areas: 1) Epitranscriptomic regulation of gene expression across the prokaryotic domain, examining RNA modifications and their regulatory roles, and 2) Post-transcriptional gene regulation via novel...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to expand scientific understanding of high-valent bis-FeIV cofactor species and their role in substrate oxidation by divergent bacterial diheme proteins. The $350,487 award, effective from September 15, 2024 to July 31, 2029, will leverage genomic data to study representative members of the annotated but uncharacterized BCCP/MAUG...