Project Grant DP2ES039816
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $167,928 under the Environmental Health Project Grant program (CFDA 93.113) on April 1, 2026. The project investigates lipoprotein-mediated nanoplastic uptake and transport across the placenta. The research addresses how micro and nanoplastics translocate into placental tissue and the role chylomicrons may play in facilitating this process. The working hypothesis posits that...
- The National Institute of Environmental Health Sciences awarded $765,348 to the University of California, Davis on April 14, 2026, under the Environmental Health program (CFDA 93.113) to investigate pollutant-adsorbed nanoplastics and their health impacts following inhalation exposure. The research addresses the formation, distribution, and neurotoxic effects of composite particles created when airborne pollutants adsorb onto nanoplastics. The study employs advanced label-free imaging...
- The National Institute of Environmental Health Sciences awarded Baylor College of Medicine $639,797 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to characterize the association between micro- and nanoplastic particle (MNP) exposure and preterm birth and to map the inflammatory and immunological mechanisms by which placental exposure to MNP drives adverse pregnancy outcomes. The research quantifies temporal patterns of MNP accumulation across 3,500 biospecimens (maternal...
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $419,375 under the Environmental Health program (CFDA 93.113) on August 10, 2026, to explore nanoplastics' neurological effects through investigation of lipid mechanisms and glial inflammation. The recipient will conduct research on micro- and nanoplastics bioaccumulation in the human brain and their molecular interactions within cerebrospinal fluid and the central nervous...
- The National Institute of Environmental Health Sciences awarded New Jersey Institute of Technology $759,977 for a Project Grant (R56ES037652) on September 1, 2026, under the Environmental Health program (CFDA 93.113). The award funds investigation of placental translocation and toxicity of environmentally relevant nanoplastics—plastic particles smaller than one micron that accumulate in human organs and may disrupt health during sensitive developmental windows. NJIT will study placental toxicity...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $157,500 Project Grant to the Regents of the University of California at Riverside on July 9, 2025, under the Environmental Health program (CFDA 93.113). This two-year award (completion date: July 8, 2027) funds pilot research investigating gene-environment interactions in autism spectrum disorder (ASD) risk through developmental exposure to per- and polyfluoroalkyl substances (PFAS), commonly...
- The National Institute of Environmental Health Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $815,546 to Icahn School of Medicine at Mount Sinai on June 22, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life chemical exposures affect executive function and brain development across adolescence. The research leverages naturally shed deciduous teeth as biomarkers to measure in utero and early childhood...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Environmental Health Sciences awarded Florida International University $772,659 on July 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate epitranscriptomic modifications and their relationship to autism spectrum disorder. The award funds research into how prenatal environmental exposures—including cadmium and per- and polyfluoroalkyl substances (PFAS)—and protective factors such as folic acid disrupt epitranscriptomic mechanisms,...
- The National Institute of Environmental Health Sciences awarded the University of Southern California $884,126 on September 19, 2025, under the Environmental Health program (CFDA 93.113) to investigate biological signatures of prenatal wildfire smoke exposure and fetal and infant growth. The recipient will examine extracellular vesicles and microRNAs as biomarkers of wildfire smoke exposure in pregnancy and their association with adverse birth outcomes. The study enrolls 466 participants from...
The National Institute of Environmental Health Sciences awarded $760,000 to the University of California, San Diego on August 26, 2026, under the Environmental Health program (CFDA 93.113) for a Project Grant to develop a placenta-brain axis-on-a-chip platform for studying prenatal neurotoxicity. The recipient will construct a physiologically integrated human co-culture system coupling placental trophoblasts, maternal immune cells, fetal endothelial cells, and cortical organoids via directional microfluidic flow to recreate the maternal-fetal-brain interface in vitro. The platform will enable real-time tracking of how environmental exposures—including pesticides, air pollutants, and medications—traverse the placental barrier and alter fetal brain development. A defining innovation incorporates next-generation genetically encoded redox biosensors for continuous, cell-type-specific monitoring of oxidative state across diverse toxicants. The research will determine how maternal exposures alter placental transport and oxidative state in fetal brain organoids, dissect how oxidative stress perturbs neurogenesis and neuronal migration, and define predictive "oxidative fingerprints" of vulnerability and resilience across diverse genetic backgrounds, including induced pluripotent stem cell lines from individuals with autism spectrum disorder. Performance occurs at UC San Diego's La Jolla, California location. The award period runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $760.0k | 8/26/26 |