Project Grant DP2DK147450
- The University of Arizona was awarded a $928,174 Project Grant from the National Science Foundation Division of Integrative Organismal Systems on November 1, 2021 to complete the project by October 31, 2024. The grant funds research into how sequential acquisition of nutritional resources modulates allocation decisions from a whole-organism perspective on life history tradeoffs. This project aligns with the goals of the Biological Sciences program administered by NSF, which provides support...
- This $645,743 National Institute of Food and Agriculture project grant from the U.S. Department of Agriculture will fund research at the University of Florida from May 2023 through April 2027 under the Agriculture and Food Research Initiative competitive grants program. The project aims to design effective behavioral nudges to improve consumers' dietary choices by investigating how induced positive consumption experiences and memories with healthy foods can shift preferences. Researchers will...
- This Project Grant award of $263,819.39 was provided by the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310). The grant aims to examine how dietary fiber can improve small intestinal nutrient sensing mechanisms that regulate food intake via a gut-brain axis, which is dependent on changes in the small intestinal microbiome. The research will identify specific small intestinal bacteria...
- This Project Grant award of $249,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to New York University aims to improve understanding of how hunger and satiety neurons regulate the activity of downstream neurons in the hypothalamus. Specifically, the research will use novel molecular and optical tools to measure and manipulate cyclic AMP (cAMP) signaling in paraventricular hypothalamic neurons that express melanocortin-4 receptors (PVHMC4R), which...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- This Project Grant award, valued at $747,133.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the Monell Chemical Senses Center to behaviorally, physiologically, anatomically, and molecularly characterize a population of neurons in the nucleus tractus solitarius (NTS) that express glucagon-like peptide-1 receptors (GLP1R) and...
- This Project Grant award of $666,229 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of the neuropeptide neurotensin (NTS) in the lateral nucleus accumbens (NACLat) to ventral tegmental area (VTA) pathway and its impact on hedonic feeding behavior. The project aims to study how NTS signaling in this neural pathway modulates reward-related feeding in mice, both on...
- The federal Project Grant award for $236,250 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), titled "Nutrient Regulation of the EEC-Vagal Network", will support research conducted by The Ohio State University to study the molecular mechanisms and environmental factors regulating the connection between enteroendocrine cells (EECs) and the vagal sensory nerve in the intestine. The proposed study will use zebrafish models and in vivo imaging to...
- This $2,560,698 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms by which animals learn about the nutrient content of foods and the neural pathways involved, with a particular focus on the lateralization of dopamine release in the brain. The research aims to reveal how...
- This $1,137,500 Project Grant award, provided under the Trans-NIH Research Support program (CFDA 93.310) by the U.S. Department of Health and Human Services' National Institutes of Health, supports research to investigate the molecular mechanisms underlying transgenerational memory in the planarian flatworm Schmidtea mediterranea. The award, with a performance period from Aug 1, 2025 to May 31, 2030, will leverage the University of Pennsylvania's expertise in regenerative biology,...
This Project Grant award of $1,276,640 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will support research at the University of Arizona to investigate the concept of "nutritional memory" in gut neuropod cells and its implications for food preferences, development, and diet-related diseases. The three-year project aims to: 1) characterize the sensory landscape and nutrient receptors of gut neuropod cells, 2) elucidate how early-life dietary exposure shapes the transcriptome, epigenome, and proteome of long-lived neuropod cells to influence lifelong food preferences, and 3) establish causality and explore therapeutic potential by ablating long-lived neuropod cells and assessing the impact on food preferences and metabolic health. The research has the potential to revolutionize the understanding of nutrition by identifying the molecular mechanisms underlying "nutritional memory" and developing innovative interventions to reprogram unhealthy food preferences and combat diet-related diseases. The project will be conducted by the University of Arizona, a prominent public research institution, with a collaborative team of experts in the field.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/16/25 |