The New York University (NYU) School of Medicine was awarded a $1,525,500 Project Grant by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant funding, which runs from September 1, 2024 to August 31, 2027, supports the development of new technologies to address two major bottlenecks in the chimeric antigen receptor (CAR) T cell therapy development process: identifying tumor-specific antigens and engineering antigen-specific receptors. Key activities include creating a comprehensive immunoproteomic search tool to uncover tumor-specific targets, developing strategies for identifying logic-gated CAR targets, and building high-throughput screening systems to efficiently generate and evaluate thousands of antigen-specific CAR clones. The grant also explores "reverse engineering" approaches to develop novel CAR T cell therapies by studying successful immune checkpoint inhibitor responses in cancer patients. Overall, this multi-pronged research aims to transform the development of more effective and safer immunotherapies, with the potential to benefit a broader population of cancer patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.5m | 8/13/24 |