Project Grant R21CA286304

Award Date 7/8/24
Completion Date 6/30/26
Dollars Obligated $828K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44195, USA
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This federal Project Grant award for $1,108,391.72, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research at The Leland Stanford Junior University to define the optimal characteristics of chimeric antigen receptor (CAR) T cells for the treatment of large B-cell lymphoma (LBCL). The key research goals are: (1) to identify the most therapeutically relevant CAR T cell subsets in LBCL patients, and (2) to overcome immune suppression by CAR T...
This $604,627 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by Trustees of Dartmouth College to deconvolve the heterogeneity of chimeric antigen receptor (CAR) T cells and engineer durable antitumor immunity. The project aims to understand how individual CAR T cell subsets behave in vivo and develop strategies to program CAR T cells to generate protective memory T cells. Key objectives include using dynamic lineage recording to...
This $1,477,396 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to develop an innovative approach to enhance the efficacy and durability of CD19-targeted CAR T-cell therapy for B-cell non-Hodgkin's lymphoma (B-NHL). The key elements include: Selecting cytomegalovirus (CMV)-specific T cells for modification with a CD19-targeting CAR, and then infusing the resulting bi-specific CMV-CD19 CAR T cells into patients. Inducing expansion of the...
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) is providing $827,942.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate a novel inhibitory receptor that regulates the persistence and function of chimeric antigen receptor (CAR)-engineered T cell therapy for lymphoma.

The key objectives are to: 1) examine the causal role of this inhibitory receptor axis in impairing the therapeutic efficacy of murine CAR-T cells, and 2) examine the expression of this inhibitory receptor in human CAR-T cells and test effects of blocking this receptor to augment CAR-T function. The award period is from July 8, 2024 to June 30, 2026. If successful, these studies will guide future efforts to develop more potent CAR-T therapies to improve clinical outcomes for lymphoma patients.

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