This federal Project Grant award from the National Cancer Institute (under CFDA 93.395 - Cancer Treatment Research) provides $513,859 to the Dana-Farber Cancer Institute, Inc. in Boston, MA to develop a novel platform for persistent adoptive cellular therapy using hematopoietic stem cell (HSC)-derived chimeric antigen receptor (CAR)-expressing natural killer (NK) cells. The project aims to leverage naturally occurring NK-specific regulatory elements to restrict CAR expression to the NK cell lineage, addressing the limitations of previous CAR-NK cell therapies by enabling long-term, continuously renewing, and safe anti-tumor immunity. The 5-year project commenced on August 1, 2024 and will investigate the feasibility and efficacy of this "HSC CAR-NK cell factory" approach across multiple in vivo models. The research seeks to provide a transformative solution to the high relapse rates observed with current CAR T-cell therapies for hematologic malignancies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $513.9k | 7/25/24 |