The Regents of the University of California, San Francisco (UCSF) has been awarded a $1,453,500 Project Grant under the Trans-NIH Research Support (CFDA 93.310) program, administered by the National Institutes of Health (NIH). The grant, titled "Simulating Ancestrally Unbiased Tumor Evolution to Interrogate Drug Resistance Among Cancer Patients of Distinct Ancestries," aims to develop an immunocompetent organoid-based tumor graft system, called BRUTE (Barcoded Unsupervised Tumor Evolution), to investigate how the anatomic niche, immune system, and molecular alterations influence tumor evolution and drug resistance in an ancestrally unbiased manner. This research seeks to identify and target the molecular drivers that are enriched among non-European American cancer patients, particularly African-American prostate cancer patients who face higher risks of disease progression and mortality. The grant period runs from September 19, 2023, to August 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.5m | 9/19/23 |