Project Grant R01CA282475

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $696K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
California, USA
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  1. Synthesize and evaluate analogues of the nSMase2 inhibitor PDDC to improve its potency, solubility, and pharmacokinetics. The Johns Hopkins University will support the analog design and in vitro testing.

  2. Assess the efficacy and tolerability of PDDC and optimized analogues in multiple mouse syngeneic tumor models, including evaluating their impact on immune cell infiltration.

  3. Evaluate the efficacy and tolerability of the optimized PDDC analogues in human cancer models, assessing their ability to block tumor exosome production and enhance immune cell targeting of cancer cells.

The award period runs from September 1, 2024 to August 31, 2029, with the goal of identifying 1-2 nSMase2 inhibitor prodrug candidates suitable for IND-enabling studies.

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