This Project Grant award, provided by the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program, aims to investigate the biological mechanisms driving racial disparities in outcomes for head and neck cancer, particularly among Black patients. The $714,062 award will fund two main objectives over a period of 5 years: Developing a tailored RNA prognostic model to enhance survival predictions for early-stage oral cancer in Black populations, by identifying gene expression signatures associated with disease progression. Examining the role of long non-coding RNAs at the 8q24.21 genomic locus in modulating tumor aggressiveness, especially in Black patients who are more likely to have amplification at this locus. The research will explore how this amplification impacts tumor proliferation, histopathology, gene expression, and progression, with a focus on the CD44-Hippo signaling axis for potential personalized treatment strategies. The proposed research aims to bridge the survival gap, advance the understanding of oral cancer biology in patients of African ancestry, and lead to better-targeted therapies and improved prognostic tools.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $714.1k | 4/11/25 |