Project Grant 2611572
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $900,000 Project Grant to the University of Pennsylvania on September 15, 2025, with completion targeted for August 31, 2028. This collaborative research initiative, funded under the Biological Sciences program (CFDA 47.074), investigates the mechanism of transcription factor (TF) functional divergence through "differential usage of shared binding sites"...
- Federal Project Grant Award Summary The Pennsylvania State University received a $1.0 million Project Grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), effective August 1, 2025 through July 31, 2028. This award funds fundamental research investigating the three-dimensional (3D) structural and mechanistic underpinnings of euchromatin and heterochromatin formation in human and other eukaryotic cells. The primary deliverable is scientific...
- Federal Project Grant Award Summary The National Science Foundation (NSF), Division of Molecular and Cellular Biosciences, awarded $622,842 to the University of Pennsylvania on May 1, 2026, under the Biological Sciences program (CFDA 47.074) to support collaborative research on zygotic genome activation (ZGA) in fruit fly embryos. This project will deliver research outputs investigating how cells measure and respond to changes in the nuclear-to-cytoplasmic (N/C) ratio to control the timing of...
- Federal Grant Award Summary The Johns Hopkins University received a $1,199,593 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), awarded September 1, 2025, with a completion date of August 31, 2029. This grant supports fundamental research to advance understanding of nucleosome mobility and chromatin dynamics through single-molecule manipulation techniques. The project will develop and apply...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $880,000 to the University of Massachusetts Lowell under the Biological Sciences program (CFDA 47.074) for a five-year CAREER grant (June 1, 2026 – May 31, 2031). The project investigates how transgenerational chromatin landscapes regulate cell fate and gene expression in Caenorhabditis elegans, focusing on the mechanisms of epigenetic inheritance—specifically, which histone...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $427,615 to the Regents of the University of Michigan (effective August 1, 2026, through July 31, 2029) under the Biological Sciences program (CFDA 47.074) to support collaborative research on epigenetic silencing mechanisms. The primary deliverable is fundamental scientific research investigating how intrinsically disordered regions (IDRs) of proteins regulate the...
- Federal Project Grant Award Summary The National Science Foundation (NSF) awarded $1.5M to the Van Andel Research Institute under the Biological Sciences program (CFDA 47.074) to support fundamental research on epigenetic regulation and gene expression control. The four-year project, initiated July 1, 2026 and concluding June 30, 2030, will investigate how asymmetric histone and DNA modifications within individual nucleosomes coordinate to regulate developmental gene expression and cell type...
- Federal Project Grant Award Summary The Pennsylvania State University received a $425,667 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through January 31, 2031. This award supports fundamental research to elucidate the molecular mechanisms of chromatin remodeling and histone deacetylation—two critical enzyme families essential for regulating DNA transcription,...
- Federal Project Grant Award Summary Brown University received a $1.2 million Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), awarded July 1, 2026, with completion expected by June 30, 2030. The research investigates the fundamental mechanisms of base excision repair (BER) within nucleosomes—the primary structural units of chromatin—to advance understanding of how DNA repair enzymes...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $1.2 million to the University of California, Davis under the Biological Sciences program (CFDA 47.074) on July 15, 2026, with a completion date of June 30, 2030. This Project Grant supports fundamental research into gene-specific nuclear messenger ribonucleoprotein (mRNP) assembly and quality control mechanisms. The research focuses on understanding how genetic...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $1.3 million to the University of Pennsylvania under the Biological Sciences program (CFDA 47.074) for the project "Dissecting the HIRA/HIR Chaperone Complex in the Chromatin Landscape." The award, effective July 1, 2026 through June 30, 2029, funds fundamental research into the structural and biochemical mechanisms of the HIRA/HIR (histone regulatory A/histone regulatory) protein complex, with emphasis on its role in replication-independent histone H3/H4 deposition at gene promoters and transcriptionally active regions. The research deliverables include mechanistic understanding of nucleosome assembly, chromatin regulation, genome defense mechanisms against viral DNA, and identification of factors controlling this essential cellular machinery using yeast as a model system. Beyond laboratory research outputs, the award supports educational and workforce development components through an established ten-year international partnership facilitating student exchange visits and integration of advanced biochemical and computational structural biology technologies into university curricula. The project is designed to generate fundamental knowledge applicable to cellular health, aging, and antiviral defense while developing the next generation of interdisciplinary scientists equipped to address complex challenges in biotechnology and biomedicine.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 6/25/26 |