Project Grant 2603177
- Federal Project Grant Award Summary The National Science Foundation (NSF) awarded Dartmouth College $748,252 through the Biological Sciences program (CFDA 47.074) to support collaborative research on the mechanisms of microbial ethanol inhibition in Clostridium thermocellum. The three-year project, which commenced October 1, 2026 and will conclude September 30, 2029, investigates how ethanol toxicity affects cellulolytic thermophilic bacteria capable of converting plant material directly into...
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $500,000 Project Grant awarded August 1, 2025, through the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The award funds development of a machine learning (ML) model designed to enable real-time decision-making during fermentation process scale-up and commercialization. The tool will predict the technical and economic impact of...
- The National Science Foundation (NSF), through its Engineering (ENG) program (CFDA 47.041), has awarded a $219,985 Project Grant to the University of Wisconsin System to conduct research aimed at expanding the substrate range of the microbe Clostridium thermocellum. The key objectives are to: 1) characterize the organism's substrate transport and central metabolism to identify factors limiting its substrate range, 2) identify mutations that allow growth on alternative substrates, and 3) use...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,000,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Madison. The 3-year grant, effective September 1, 2023, supports a collaborative research project between the University of Wisconsin-Madison and members of the Department of Energy's Agile Biofoundry to investigate bacterial transporters and engineer them for superior properties in...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $300,000 to the University of California, Berkeley under the Biological Sciences program (CFDA 47.074) for collaborative research on engineering synthetic multi-kingdom anaerobic communities to produce volatile fatty acids from biomass. The project award, dated July 15, 2026, with an ultimate completion date of June 30, 2029, supports basic research aimed at advancing...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded University of California, Santa Barbara $800,000 under the Biological Sciences program (CFDA 47.074) on July 15, 2026, for a collaborative research project extending through June 30, 2029. This project will develop synthetic anaerobic microbial consortia designed to convert plant and agricultural waste into volatile fatty acids (VFAs), a value-added commodity chemical. The...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $629,896 Project Grant to the University of Wisconsin-Madison on February 15, 2021 with a completion date of January 31, 2026. The grant supports research under the Biological Sciences program (CFDA 47.074) to advance understanding of heterogeneous decision-making in individual microbes and populations through synthetic approaches. As the official program description indicates, the Biological Sciences...
- Federal Project Grant Award Summary The National Science Foundation's Division of Chemistry is supporting fundamental research at the University of Wisconsin–Madison under the Mathematical and Physical Sciences program (CFDA 47.049) with a $600,000 project grant awarded September 1, 2025, with a completion date of August 31, 2028. Professor Helen Blackwell will investigate the chemical signals that gram-positive bacteria use for cell-cell communication through quorum sensing (QS), specifically...
- Federal Grant Award Summary The National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $902,786 collaborative research project grant to the University of Wisconsin-Madison, effective October 1, 2025, through September 30, 2029, under the Engineering program (CFDA 47.041). This project will deliver advanced computational modeling and experimental research capabilities focused on accelerating the discovery and design of dynamically...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $153,452 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), awarded March 1, 2026, with completion by July 31, 2026. This collaborative research initiative focuses on developing microbial strains with minimal genomes capable of functioning in supercritical carbon dioxide (ScCO2) environments for integrated...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,451 Project Grant to the University of Wisconsin-Madison on October 1, 2026, through the Biological Sciences program (CFDA 47.074) to support collaborative research on microbial ethanol inhibition mechanisms in Clostridium thermocellum. The three-year project, scheduled for completion by September 30, 2029, will investigate whether metabolic disruptions within microbial cells—rather than membrane damage—represent the primary mechanism of alcohol toxicity in industrial biofuel production processes. By clarifying the true mechanisms of ethanol inhibition in this cellulolytic thermophile, the research will generate foundational knowledge essential for engineering microbes capable of tolerating higher alcohol concentrations, thereby enabling more efficient and economical cellulosic ethanol production from agricultural waste and wood feedstocks. In addition to advancing biofuel biotechnology capabilities aligned with NSF priorities in biotechnology and advanced materials manufacturing, the project will deliver educational and community engagement outcomes. The award will provide interdisciplinary training for graduate, undergraduate, and high school students across UW-Madison, Dartmouth College, and partner institutions in New Hampshire, while an integrated outreach program will connect biofuel research findings to the local brewing and distilling community to enhance public understanding of industrial bioeconomy applications.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.5k | 6/25/26 |