The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,000,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Madison. The 3-year grant, effective September 1, 2023, supports a collaborative research project between the University of Wisconsin-Madison and members of the Department of Energy's Agile Biofoundry to investigate bacterial transporters and engineer them for superior properties in biomanufacturing strategies. The key products and services to be delivered under this grant include:
-
Developing a suite of synthetic biology tools to close knowledge gaps surrounding transporters in gram-negative bacteria, enabling improved control of chemical inputs and outputs in microbial biomanufacturing processes. This includes conducting genome-wide fitness assays, engineering strains for gain-of-function experiments, and applying protein engineering techniques to enhance transporter function.
-
Contributing new data on transporter function to systems biology models to advance metabolic engineering and biomanufacturing research. The project also provides synthetic biology training to graduate and undergraduate students, and partners with undergraduate research programs to mentor underrepresented researchers.
Generated 4/30/24, 3:19 AM